CD1a
CD1a is one of the group 1 human CD1 molecules, presenting lipid and glycolipid antigens to T cells in an MHC class I-like fold. Its hydrophobic antigen-binding groove accommodates ligands such as dideoxymycobactin lipopeptides from Mycobacterium tuberculosis, which activate CD1a-restricted T cells. Expression is prominent on Langerhans cells of the epidermis and on cortical thymocytes, making CD1a the classic immunohistochemical marker for Langerhans cell histiocytosis and a standard tool for identifying dendritic cell subsets. CD1a-restricted autoreactive T cells that recognize endogenous lipids have been described, implicating the molecule in skin inflammatory circuits. Unlike MHC molecules, the CD1 genes show little polymorphism.
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CD1a Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
