CD74
CD74, the MHC class II-associated invariant chain (Ii), is a type II transmembrane glycoprotein encoded by a gene on chromosome 5q33. In the endoplasmic reticulum it assembles with MHC class II alpha/beta heterodimers, blocking premature peptide loading and delivering the complexes to endosomal compartments where cleavage leaves the CLIP fragment for exchange. Beyond chaperoning antigen presentation, membrane CD74 acts as a receptor for macrophage migration inhibitory factor (MIF), and proteolytic release of its intracellular domain activates NF-kappaB-dependent transcription. CD74 is constitutively expressed on B cells and antigen-presenting cells, and its high density on malignant B cells in multiple myeloma is exploited by antibodies such as milatuzumab.
-
CD74 Recombinant Proteins (4)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
