Puxitatug
Based on 1 Customer Validation
Puxitatug (INT-016; AZD8205 Antibody) is a monoclonal antibody targeting VTCN1/B7-H4. Puxitatug can be used to synthesize antibody-drug conjugates (ADCs), such as Puxitatug samrotecan (HY-171689), which can be applied to various solid tumors. Puxitatug can also be used for researching adjuvant therapies for gastric cancer.
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- Purity : 99.00%
- CAS No.: 2760250-47-1
- 분자량:145 kDa
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보관:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
제품 설명
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
B7-H4/VTCN1
In Vitro
Puxitatug samrotecan (AZD 8205) (HY-171689) is a B7-H4-directed antibody-drug conjugate (ADC) bearing a Topoisomerase I inhibitor (TOP1i) payload. Puxitatug samrotecan improves HR+/HER2- breast cancer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
신청
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded Puxitatug on AHC2 biosensor, can bind B7-H4 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78073) with an affinity constant of 4.217E-09 M as determined in BLI assay. -
Flow cytometric analysis of 1X106 Jurkat cells with Puxitatug (HY-P990059, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2760250-47-1
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Appearance Liquid
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분자량 145 kDa
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Color Colorless to light yellow
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SMILES
[Puxitatug]
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Synonyms
INT-016; AZD8205 Antibody
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Puxitatug
- 2760250-47-1
- INT-016
- AZD8205 Antibody
- INT016
- INT 016
- ADC Antibodies
- CD276/B7-H3
- topoisomerase I inhibitor
- cysteinylation
- interchain disulfide bond reformation
- biliary tract cancer
- B7-H4-expressing cells
- B7-H4
- retro-Michael reaction
- thio-succinimide ring hydrolysis
- glutathione adduct formation
- mouse models
- Inhibitor
- inhibitor
- inhibit