Cutamesine
Based on 7 publication(s) in Google Scholar
Cutamesine (SA4503) is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM). Cutamesine has antidepressant effects.
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- Purity: 99.18%
- CAS No.: 165377-43-5
- 화학식: C23H32N2O2
- 분자량:368.51
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Cutamesine
More- Cell Death Dis. 2025 Jul 2;16(1):485. [Abstract]
- Neural Regen Res. 2025 Aug 1;20(8):2325-2336. [Abstract]
- Pharmaceuticals (Basel). 2025 Mar 24;18(4):455. [Abstract]
- Eur J Pharmacol. 2023 May 5:946:175647. [Abstract]
- Mol Neurobiol. 2025 Nov 24;63(1):163. [Abstract]
- Mol Neurobiol. 2025 Jun 1. [Abstract]
- Neurochem Int. 2025 Jan 28:105937. [Abstract]
All Sigma Receptor Isoforms
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Biological Activity
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Sigma 1 Receptor 17.4 nM (IC50) |
Sigma 2 Receptor 1784 nM (IC50) |
Exposure of the neurons to H2O2 induced cell death, while pretreatment with Cutamesine inhibits neuronal cell death. Cutamesine also reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
A single injection of 1 mg/kg i.p. of Cutamesine produced a significant decrease and increase in the number of spontaneously active SNC and VTA DA neurons, respectively[3].
The repeated administration (one injection per day for 21 days) of 0.3 and 1 mg/kg i.p. of Cutamesine produced a significant increase in the number of spontaneously active VTA DA neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 165377-43-5
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Appearance Solid
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분자량 368.51
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화학식 C23H32N2O2
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Color Off-white to light yellow
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SMILES
COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC
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Synonyms
SA4503; AGY 94806
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
FGFR inhibitors promote the autophagic degradation of IFN-γ-induced PD-L1 and alleviate the PD-L1-mediated transcriptional suppression of FGFR3-TACC3 in non-muscle-invasive bladder cancer. [Abstract]2025 Jul 2;16(1):485. PMID: 40603902 -
Neural Regen Res
Hypidone hydrochloride (YL-0919) ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation. [Abstract]2025 Aug 1;20(8):2325-2336. PMID: 39359091 -
Pharmaceuticals (Basel)
Hypidone Hydrochloride (YL-0919), a Sigma-1 Receptor Agonist, Improves Attention by Increasing BDNF in mPFC. [Abstract]2025 Mar 24;18(4):455. PMID: 40283892 -
Eur J Pharmacol
Sigma-1 receptor agonist properties that mediate the fast-onset antidepressant effect of hypidone hydrochloride (YL-0919). [Abstract]2023 May 5:946:175647. PMID: 36898424 -
Mol Neurobiol
Presence of Astrocytic S1R/5-HT1A Heterocomplex in the mPFC: A Putative Link to S1R Activation Mediated Faster Antidepressant-Like Effects. [Abstract]2025 Nov 24;63(1):163. PMID: 41284099 -
Mol Neurobiol
Sigma-1 Receptor Activation Alleviates iBRB Dysfunction after I/R Injury by Inhibiting Endoplasmic Reticulum Stress-Dependent Autophagy. [Abstract]2025 Jun 1. PMID: 40450632 -
Neurochem Int
Sigma-1 receptor activation produces faster antidepressant-like effect through enhancement of hippocampal neuroplasticity: Focus on sigma-1-5-HT1A heteroreceptor complex. [Abstract]2025 Jan 28:105937. PMID: 39884578
순도&문서
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8. [Content Brief]
[2]. Ono Y, et al. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett. 2014 Jan 24;559:174-8. [Content Brief]
[3]. Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33(2):129-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cutamesine Related Classifications
HY-14813 Related Classifications
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