Salacinol
Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC50 = 3.2 μg/mL, Ki = 0.31 μg/mL), sucrase (IC50 = 0.84 μg/mL, Ki = 0.32 μg/mL), and isomaltase (IC50 = 0.59 μg/mL, Ki = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus.
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- CAS No.: 200399-47-9
- 화학식: C9H18O9S2
- 분자량:334.36
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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α‑glucosidase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
0.5 μM
Compound: 12, Salacinol
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Inhibition of maltase in human Caco-2 cell membrane
Inhibition of maltase in human Caco-2 cell membrane
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[PMID: 18258441] |
Salacinol (300 mg/L; 30 min) significantly inhibits porcine pancreatic lipase activity by 12.6%[1].
Salacinol (100 mg/L; 2 h) significantly inhibits rat adipose tissue-derived lipoprotein lipase activity by 13.6%[1].
Salacinol (100 mg/L; 18 h) reduces remaining triglyceride content in rat epididymal fat-derived adipocytes to 75.3% of vehicle control[1].
Salacinol (30 min) competitively inhibits rat small intestinal brush border membrane vesicle maltase, sucrase, and isomaltase with IC50 values of 3.2, 0.84, and 0.59 μg/mL, respectively, and Ki values of 0.31, 0.32, and 0.47 μg/mL, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sucrose-induced sucrose-induced Wistar (male, weight 130-170 g)[2]
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Dosage:1.3 mg/kg; 2.5 mg/kg; 5 mg/kg; 10 mg/kg
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Administration:p.o.
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Result:Significantly inhibited the increase in serum glucose.
Chemical Information
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CAS No. 200399-47-9
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분자량 334.36
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화학식 C9H18O9S2
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SMILES
OC[C@@H]([C@@H](C[S@+]1[C@@H]([C@H]([C@@H](C1)O)O)CO)O)OS(=O)([O-])=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Salacinol Related Classifications
HY-119741 Related Classifications
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- Salacinol
- 200399-47-9
- Glycosidase
- Lipase
- isomaltase
- rat small intestinal brush border membrane vesicle
- rat adipose tissue-derived lipoprotein lipase
- diabetes mellitus
- sucrase
- porcine pancreatic lipase
- Salacia reticulata
- rat intestinal maltase
- α-glucosidase
- rat epididymal fat-derived adipocytes
- Inhibitor
- inhibitor
- inhibit