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Cat. No.: HY-119386

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SAS-0132

SAS-0132 is a selective Sigma 2 receptor (Sig2R) antagonist (K_i: 90 nM) that can cross the blood-brain barrier. SAS-0132 is capable of regulating intracellular Ca²⁺ levels and modulating PGRMC1-related pathways. SAS-0132 exhibits neuroprotective activity and can improve cognitive impairment in Alzheimer's disease mice. SAS-0132 can be used in the research of neurocognitive disorders such as Alzheimer's disease.

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CAS No.: 1644629-60-6
화학식: C₂₄H₂₉N₃O₂
분자량:391.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

SAS-0132 Chemical Structure

CAS No.: 1644629-60-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Sigma Receptor Isoforms :

All Calcium Channel Isoforms :

Chemical Information

CAS No. 1644629-60-6
분자량 391.51
화학식 C₂₄H₂₉N₃O₂
SMILES

O=C(N1CCC2C3=CC=C(N4CCN(CC4)C)C=C3C1C2)OCC5=CC=CC=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yi B, et al. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. J Neurochem. 2017 Feb;140(4):561-575. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
수량:

SAS-0132

All Sigma Receptor Isoforms

All Calcium Channel Isoforms