SCH 350581
SCH 350581 (AD-101) is a CCR5 antagonist. SCH 350581 inhibits HIV-1 replication, viral entry into cells, and the binding of gp120 to cell lines in primary lymphocytes.
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- CAS No.: 306293-36-7
- 화학식: C28H37F3N4O
- 분자량:502.61
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
0.03 nM
Compound: 2
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Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
Inhibition of 0.1 nM of MIP-1beta induced migration of recombinant mouse pro-B cell line BA/F3 expressing human CCR5
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[PMID: 12565973] |
| U-87MG ATCC | IC50 |
0.2 nM
Compound: 2
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Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM
Compound was tested for inhibiting HIV (ADA) entry into cells; Range is 0.2-2.0 nM
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[PMID: 12565973] |
| U-87MG ATCC | IC50 |
0.5 nM
Compound: 18
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Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells
Inhibition of the entry of HIV-1 reporter virus (ADA) into U-87 cells
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[PMID: 11585438] |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 306293-36-7
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Appearance Solid
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분자량 502.61
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화학식 C28H37F3N4O
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Color White to off-white
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SMILES
O=C(C1=C(C)C=CN=C1C)N2CCC(N3C[C@H](C)N([C@H](C4=CC=C(C(F)(F)F)C=C4)C)CC3)(C)CC2
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Synonyms
AD-101
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
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Data Sheet (265 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SCH 350581 Related Classifications
HY-123768 Related Classifications
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