Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Cat. No.: HY-P4160
CAS No.: 634586-40-6
Synonyms: THG113.31; ILGHXDYK
Target:
연구분야:
Cat. No.: HY-P992101
CAS No.: 3057276-00-0
Synonyms: AUR-200
Target:
연구분야:
Cat. No.: HY-W011086R
CAS No.: 78-30-8
Synonyms: Tri-O-cresyl phosphate (Standard); TOTP (Standard)
Cat. No.: HY-W017448R
CAS No.: 24307-26-4
Synonyms: N,N-Dimethylpiperidinium chloride (Standard); PIX (Standard)
Cat. No.: HY-W040047
CAS No.: 1852-49-9
Target:
Cat. No.: HY-W088066A
CAS No.: 10101-89-0
Cat. No.: HY-W162231
CAS No.: 91216-38-5
Target:
연구분야:
HC102A is an Antibacterial agent and an inhibitor of DosS and DosT histidine sensor kinases, with an IC50 of 1.9 μM against Mycobacterium tuberculosis DosS. HC102A does not alter the heme redox state of sensor kinases. HC102A reduces triacylglycerol synthesis and accumulation, decreases the survival rate of Mtb under non-replicating persistent and hypoxic conditions, and enhances the sensitivity of Mtb to Isoniazid (HY-B0329). HC102A can be used in research related to tuberculosis .
Cat. No.: HY-W269032
CAS No.: 3598-68-3
연구분야:
Lig4-4 is an orally active and selective TREK-1 inhibitor, with an IC50 of 2.06 μM in rats. Lig4-4 improves neuronal viability, reduces cell apoptosis by upregulating cleaved-caspase-3 and downregulating Bcl-2, and decreases infarct volume. Lig4-4 exerts a neuroprotective effect against cerebral ischemia injury. Lig4-4 can be used in studies related to cerebral ischemia .
Cat. No.: HY-W402074
CAS No.: 16275-44-8
Synonyms: Butenolide
Cat. No.: HY-W747703
CAS No.: 1163160-18-6
Synonyms: Benzoylglycine-13C6
Cat. No.: HY-W750960
CAS No.: 1377605-22-5
Biotinylated isoxazole is a chemical probe that selectively precipitates proteins containing prion-like low-complexity domains and Cross-β prion-like polymers through recognition of Cross-β structure. Biotinylated isoxazole induces precipitation of proteins containing intrinsically disordered regions through microcrystal formation in solution. Biotinylated isoxazole enables enrichment of Amyloid oligomers for ELISA-based detection. Biotinylated isoxazole decreases Gems and increases misfolded PFN1 aggregates .
Cat. No.: HY-W758396
Synonyms: N,N-Dimethylpiperidinium-d16 chloride; PIX-d16
Cat. No.: HY-W774926
CAS No.: 82523-59-9
Synonyms: NRDC-143-d6
Cat. No.: HY-W014507
CAS No.: 84-11-7
Synonyms: 9,10-PQ
9,10-Phenanthrenequinone (9,10-PQ) is a quinone environmental pollutant that induces oxidative stress. 9,10-Phenanthrenequinone upregulates AKR1B10 and NQO1, and promotes Nrf2 nuclear translocation, MEK/ERK phosphorylation, MMP-2 expression, caspase-3/9/8 activation, Bax increase, Bcl-2/Bcl-XL decrease, PARP activation, E-cadherin decrease, and 26S proteasome inhibition. 9,10-Phenanthrenequinone oxidizes thiols, causes oxidative damage to CuZn-SOD, depletes intracellular GSH, induces lipid peroxidation, and mediates mitochondrial dysfunction, p53 activation, and initiation of caspase-dependent apoptosis. 9,10-Phenanthrenequinone has ROS-independent toxicity pathways, and can inhibit cyclin B1 accumulation in mouse oocytes, downregulate Cdk1 activity, disrupt acentrosomal MTOC assembly and bipolar spindle formation, and arrest meiotic progression. 9,10-Phenanthrenequinone can be used in research on lung cancer, neuroblastoma, and cardiovascular diseases .
Cat. No.: HY-100421R
CAS No.: 1628208-23-0
연구분야:
CPI-455 (Standard) is the analytical standard of CPI-455 (HY-100421). This product is intended for research and analytical applications. CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents .
Cat. No.: HY-100432R
CAS No.: 877963-94-5
Target:
LOC14 (Standard) is the analytical standard of LOC14 (HY-100432). This product is intended for research and analytical applications. LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding .
LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .
Cat. No.: HY-100900R
CAS No.: 1991986-30-1
Target:
연구분야:
ML364 (Standard) is the analytical standard of ML364 (HY-100900). This product is intended for research and analytical applications. ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 μM) with anti-proliferative activity, which direct binds to USP2 (Kd=5.2 μM), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP .
Target:
SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 μM). SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain .
Cat. No.: HY-101563R
CAS No.: 1616392-22-3
Synonyms: GSK3326595 (Standard); EPZ015938 (Standard)
Pemrametostat (Standard) (GSK3326595 (Standard); EPZ015938 (Standard)) is the analytical standard of Pemrametostat (HY-101563). This product is intended for research and analytical applications. Pemrametostat (GSK3326595) is a protein arginine methyltransferase 5 (PRMT5) inhibitor. Pemrametostat decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. Pemrametostat can be used for research of relapsed/refractory mantle cell lymphoma .
Cat. No.: HY-101872AR
CAS No.: 2703752-81-0
Target:
연구분야:
GSK-872 hydrochloride (Standard) is the analytical standard of GSK-872 hydrochloride (HY-101872A). This product is intended for research and analytical applications. GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
