SHLP2
Based on 1 Customer Validation
SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 binds to mitochondrial complex 1. SHLP2 improves mitochondrial metabolism by increasing respiration and biogenesis, reducing ROS, and decreasing mtDNA oxidation. SHLP2 also regulated energy homeostasis through the activation of hypothalamic neurons. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases, such as age-related macular degeneration and Parkinson’s disease.
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- Purity: 99.09%
- CAS No.: 1191923-93-9
- 화학식: C142H214N36O35S
- 분자량:3017.50
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
SHLP2 (2.5 μM, 24 h) protects against mitochondrial dysfuction in SH-SY5Y cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:2.5 μM
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Incubation Time:24 h
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Result:Reduced the MPP + -induced cell death.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1191923-93-9
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Appearance Solid
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분자량 3017.50
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화학식 C142H214N36O35S
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Color White to off-white
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Synonyms
Small humanin-like peptide 2
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Sequence
Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser
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Sequence Shortening
MGVKFFTLSTRFFPSVQRAVPLWTNS
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 100 mg/mL (33.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Nashine S, et al. Effects of mitochondrial-derived peptides (MDPs) on mitochondrial and cellular health in AMD[J]. Cells, 2020, 9(5): 1102. [Content Brief]
[2]. Kim, S. J., et al., (2024). A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease. Molecular psychiatry, 29(2), 505–517. [Content Brief]
[3]. Kim, S. K., et al., (2023). Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons. Nature communications, 14(1), 4321. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3314 mL | 1.6570 mL | 3.3140 mL | 8.2850 mL |
| 5 mM | 0.0663 mL | 0.3314 mL | 0.6628 mL | 1.6570 mL | |
| 10 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL | 0.8285 mL | |
| 15 mM | 0.0221 mL | 0.1105 mL | 0.2209 mL | 0.5523 mL | |
| 20 mM | 0.0166 mL | 0.0829 mL | 0.1657 mL | 0.4143 mL | |
| 25 mM | 0.0133 mL | 0.0663 mL | 0.1326 mL | 0.3314 mL | |
| 30 mM | 0.0110 mL | 0.0552 mL | 0.1105 mL | 0.2762 mL |
SHLP2 Related Classifications
HY-P10409 Related Classifications
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