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Cat. No.: HY-189060

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SLU-12091

SLU-12091 is a phosphodiesterase (PDE) inhibitor and the more potent enantiomer of rac-11. SLU-12091 inhibits the activities of hPDE5, hPDE11, hPDE2A1, hPDE3A, hPDE3B, hPDE4A1A and hPDE4D2. SLU-12091 inhibits the growth of Cryptosporidium parvum without inhibiting the growth of host cells at the highest concentration tested. SLU-12091 can be used for the research of cryptosporidiosis.

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CAS No.: 3065124-09-3
화학식: C₂₃H₂₃BFN₅O₂
분자량:431.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SLU-12091 Chemical Structure

CAS No.: 3065124-09-3

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

PDE5

PDE11

PDE2A

PDE3A

PDE3B

PDE4A1

PDE4D2

All Phosphodiesterase (PDE) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-8	EC50	0.011 μM	Inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion. Inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.	42593902
HCT-8	EC90	0.020 μM	90% inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion. 90% inhibition of Cryptosporidium parvum asexual replication in human colon carcinoma HCT-8 cells assessed by automated fluorescence microscopy after 48 h incubation post-invasion.	42593902

In Vitro

SLU-12091 (ent2-11) (0.011 μM; 48 h) potently inhibits Cryptosporidium parvum replication in HCT-8 cells with an EC₅₀ of 11 nM and shows no cytotoxicity against HCT-8 cells up to 50 μM^[1].
SLU-12091 (0.1-10 μM) inhibits multiple human PDE enzymes, with the strongest activity against hPDE5, hPDE4D2, hPDE3A, hPDE3B, and hPDE2A1 at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3065124-09-3
분자량 431.27
화학식 C₂₃H₂₃BFN₅O₂
SMILES

FC1=CC=C(C=C1)CNC2=NC(C3=CC=C4B(O[C@H](C4=C3)C)O)=NC5=C2C(CC)=NN5C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Guin S, et al. Structure-Activity Relationship Study of Anti-Cryptosporidium Benzoxaboroles Yields Enhanced Potency and Curative Efficacy. Journal of medicinal chemistry. 2026 Aug 13;69(15):19355-19370.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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