Sodium caseinates
Based on 1 Customer Validation
Sodium caseinates is a kind of sodium salts of major milk proteins, which act as protein-based biopolymers and innate immune system activators. Sodium caseinates induce granulopoiesis, activation and differentiation, promote the production of M-CSF, and increase serum levels of G-CSF and GM-CSF. Sodium caseinates inhibit the proliferation and reduce the viability of leukemia macrophage-like cells, thereby significantly improving the survival rate of mice inoculated with leukemia cells. Sodium caseinates can serve as carriers for probiotics in edible films and exhibit anti-Listeria activity. Sodium caseinates effectively protect vitamin A from degradation, enhance its stability, bioaccessibility and bioavailability, and regulate protein digestibility when complexed with vitamin A. Sodium caseinates can be applied to research related to acute monocytic leukemia and vitamin A deficiency.
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- CAS No.: 9005-46-3
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Sodium caseinates induce differentiation of mouse bone marrow band granulocytes and increase their M-CSF production in vitro[1].
Sodium caseinate (4% (w/v); 9 days at 4°C) films containing Lactobacillus acidophilus exhibit significant antilisterial activity against Listeria monocytogenes PTCC 1163 after 9 days at 4°C, while films containing Lactobacillus casei only show significant activity after 6 days at 4°C compared to control sodium caseinate films[2].
Sodium caseinates (0.5-2.0 mg/mL; 72 h) inhibits proliferation and induces macrophagic differentiation of J774 leukaemia macrophage-like cells without reducing cell viability[3].
Sodium caseinates (2.0 mg/mL; 24-120 h) inhibits proliferation of J774 leukaemia macrophage-like cells starting at 48 h and significantly reduces cell viability to ~15% after 120 h of incubation[3].
Sodium caseinates (13 μM VA; 20 h) do not exhibit cytotoxicity toward Caco-2 cells, resulting in 80-90% cell viability after 20 h of incubation with 13 μM VA[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774 leukaemia macrophage-like cells
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Concentration:0.5 mg/mL; 1.0 mg/mL; 2.0 mg/mL
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Incubation Time:72 h
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Result:Reduced J774 cell proliferation index to ~50% at 1.0 mg/mL.
Reduced J774 cell proliferation index to ~40% at 2.0 mg/mL.
Did not reduce J774 cell viability at 0.5, 1.0, and 2.0 mg/mL.
Induced macrophagic differentiation of J774 cells at 1.0 and 2.0 mg/mL.
Sodium caseinate (1 mL of 10% (w/v); i.p.; every 48 hours) increases survival of J774-induced leukaemic BALB/c mice to 60% in females and 50% in males at 160 days, while reducing splenomegaly, hepatomegaly, and tumour burden[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (male, 8-12 weeks old)[1]
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Dosage:10% (w/v) in PBS, 1 mL per dose
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Administration:i.p.; four times every 48 hours; 6 days
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Result:Increased total bone marrow leukocyte count to 34.6 × 106 cells per femur, and mononuclear cell count to 4.8 × 106 cells per femur.
Increased percentage of myeloblasts, band cells, and segmented granulocytes in bone marrow, with a corresponding decrease in lymphocyte population.
Increased BrdU incorporation in bone marrow mononuclear cells to 34.86%, and increased percentage of BrdU+/Gr-1+ granulocytic lineage cells to 64.94%.
Increased serum G-CSF levels to 3189 pg/mL, and increased bone marrow plasma G-CSF levels to 1160 pg/mL; serum GM-CSF levels were detectable at 1.25 pg/mL.
Increased granulocyte phagocytic index to 0.6.
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Animal Model:BALB/c (8-12 weeks old; female and male; intraperitoneal inoculation with 1.0×106 J774 leukaemia macrophage-like cells)[3]
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Dosage:1 mL of 10% (w/v)
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Administration:i.p.; every 48 hours
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Result:Significantly reduced splenomegaly, hepatomegaly, and solid tumour burden in leukaemic mice.
Extended survival of treated mice: 60% of female mice survived beyond 160 days, and 50% of male mice survived beyond 160 days (all untreated leukaemic mice died before 100 days).
Eliminated residual autonomous leukaemic cell growth, as mononuclear bone marrow cells isolated from treated surviving mice did not proliferate in vitro without recombinant mouse interleukin-3.
Chemical Information
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CAS No. 9005-46-3
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Appearance Solid
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Color White to off-white
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SMILES
[Sodium caseinates]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
순도&문서
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Domínguez-Melendez V, et al. Sodium caseinate induces mouse granulopoiesis. Inflamm Res. 2012;61(4):367-373. [Content Brief]
[3]. Córdova-Galaviz Y, et al. Sodium caseinate induces increased survival in leukaemic mouse J774 model. In Vivo. 2014;28(5):819-825. [Content Brief]
[4]. Rana S, et al. Effect of sodium caseinate and vitamin A complexation on bioaccessibility and bioavailability of vitamin A in Caco-2 cells. Food Res Int. 2019;121:910-918. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sodium caseinates Related Classifications
HY-139410 Related Classifications
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