SR-16434
SR-16434 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor Ki=7.49; μ-Opioid receptor Ki=2.70). SR-16434 can relieve pain.
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- CAS No.: 857262-16-9
- 화학식: C22H30N2O
- 분자량:338.49
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
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NOP receptor 7.49 (Ki) |
μ-opioid 2.70 (Ki) |
κ-opioid 219.47 (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
28.7 nM
Compound: 2
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Agonist activity at human nociceptin receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
Agonist activity at human nociceptin receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
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[PMID: 23623415] |
| CHO | EC50 |
29 nM
Compound: 2
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Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
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[PMID: 23623415] |
| CHO | EC50 |
<10000 nM
Compound: 2
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Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting analysis
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[PMID: 23623415] |
SR 16434 (10, 30 mg/kg; s.c. once daily for 9 days) produces an increase in tail-lick latency across days, induces conditioned place preference, and decreases global activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20 to 25 g male ICR mice[1]
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Dosage:10, 30 mg/kg
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Administration:s.c. for single-dose
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Result:Produced dose-dependent increase in tail-flick latency and induced antinociception.
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Animal Model:20 to 25 g male ICR mice[1]
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Dosage:10, 30 mg/kg
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Administration:s.c. once daily for 9 days
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Result:Produced an increase in tail-lick latency across days, induced conditioned place preference, and decreased global activity.
Chemical Information
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CAS No. 857262-16-9
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분자량 338.49
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화학식 C22H30N2O
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SMILES
O=C1N(C2CCN(C3C4CCCC3CCC4)CC2)C5=C(C=CC=C5)C1
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Synonyms
SR-16435 free base
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SR-16434 Related Classifications
HY-122681 Related Classifications
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