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Cat. No.: HY-161029

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T14-A24

T14-A24 is an orally active, reversible, competitive, and selective AChE inhibitor (K_i=22 nM, IC₅₀=6 nM). T14-A24 has benign BBB penetration, remarkable neuroprotective effect, and safe toxicological profile.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₄H₂₄N₆O₃S
분자량:476.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

T14-A24 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

AChE

22 nM (Ki)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vivo

T14-A24 (10 mg/kg, po) improves the Aβ1-42-induced cognitive impairment, significantly prevents the effects of Aβ1-42 toxicity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 476.55
화학식 C₂₄H₂₄N₆O₃S
SMILES

O=S(CCC1=CN(N=N1)C2=CC3=CC=CC=C3N=C2)(NCCC4=CNC5=C4C=C(OC)C=C5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tang K, et al. Microtiter plate-based chemistry and in situ screening: SuFEx-enabled lead discovery of selective AChE inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2237213. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

T14-A24

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

T14-A24 Related Classifications

HY-161029 Related Classifications