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Cat. No.: HY-107164

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Thiomarinol A

(Synonyms: 4-Hydroxythiomarinol C)

Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a K_i^app value of 19 nM.

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CAS No.: 146697-04-3
화학식: C₃₀H₄₄N₂O₉S₂
분자량:640.81

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Thiomarinol A Chemical Structure

CAS No.: 146697-04-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Antibiotic Isoforms :

In Vitro

Thiomarinol A shows antimicrobial activity with MICs of 0.002, 0.08, 0.04, 0.04, 0.50, 0.02, 0.01 µM for COL IleRS, LLMR COL IleRSV588F/V631F, LLMR COL IleRSF587V/V631F, LLMR COL IleRSV588F, IleRSV588F MupA, thiomarinol-resistant COL IleRSG593D, thiomarinol-resistant COL IleRSP606S, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 146697-04-3
분자량 640.81
화학식 C₃₀H₄₄N₂O₉S₂
SMILES

O[C@@H]([C@@]1([H])[C@@H]([C@@H]([C@H](CO1)C/C=C/[C@@H](C)[C@@H](O)C)O)O)/C(C)=C/C(OCCCCCCCC(NC2=C3C(NC2=O)=CSS3)=O)=O
Synonyms

4-Hydroxythiomarinol C
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
A. rava
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Johnson RA, et al. Inhibition of Isoleucyl-tRNA Synthetase by the Hybrid Antibiotic Thiomarinol. J Am Chem Soc. 2021 Aug 11;143(31):12003-12013. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
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수량:
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Thiomarinol A

All Antibiotic Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Thiomarinol A Related Classifications

HY-107164 Related Classifications