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Cat. No.: HY-148253

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TP-030-1

TP-030-1, a chemical probe, is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a K_i value of 3.9 nM and inhibits mRIPK1 with an IC₅₀ value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases.

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CAS No.: 2095514-75-1
화학식: C₂₃H₂₂N₄O₃
분자량:402.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TP-030-1 Chemical Structure

CAS No.: 2095514-75-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All RIP kinase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	18 nM Compound: 14	Induction of necroptosis in human HT-29 cells assessed as increase in TNFalpha/AT-406/zVAD-FMK-induced LDH release preincubated with cells followed by TNFalpha/AT-406/zVAD-FMK addition measured after 16 to 20 hrs by CytoTox 96 nonradioactive cytotoxicity Induction of necroptosis in human HT-29 cells assessed as increase in TNFalpha/AT-406/zVAD-FMK-induced LDH release preincubated with cells followed by TNFalpha/AT-406/zVAD-FMK addition measured after 16 to 20 hrs by CytoTox 96 nonradioactive cytotoxicity	[PMID: 29485864]

In Vitro

TP-030-1 inhibits HT29 necroptosis with an IC₅₀ value of 18 nM^[1].
TP-030-1 inhibits hRIPK1 with a K_i value of 3.9 nM^[1].
TP-030-1 inhibits mRIPK1 with an IC₅₀ value of 4.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2095514-75-1
분자량 402.45
화학식 C₂₃H₂₂N₄O₃
SMILES

O=C1[C@@H](N2CCC3=CN(CC4=CC=CC=C4)N=C3C2=O)COC5=CC=CC=C5N1C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Msato Yoshikawa, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships. J. Med. Chem. 2018, 61, 6, 2384–2409.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
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수량:
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TP-030-1

All RIP kinase Isoforms