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Cat. No.: HY-100443A

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trans-PX20606

(Synonyms: trans-PX-102)

3 Cited Publications

고객리뷰

Based on 3 publication(s) in Google Scholar

PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC₅₀s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.24%
CAS No.: 1268244-85-4
화학식: C₂₉H₂₂Cl₃NO₄
분자량:554.85

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

trans-PX20606 Chemical Structure

CAS No.: 1268244-85-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (3)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC₅₀s of 32 and 34 nM for FXR in FRET and M1H assay, respectively^[1].

IC₅₀ & Target

EC50: 32 nM (FXR in FRET assay), 34 nM (FXR in M1H assay)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	186 nM Compound: 7a	Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay	[PMID: 27268696]
HEK293	EC₅₀	47 nM Compound: 7b	Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay	[PMID: 27268696]

Chemical Information

CAS No. 1268244-85-4
Appearance Solid
분자량 554.85
화학식 C₂₉H₂₂Cl₃NO₄
Color White to off-white
SMILES

O=C(O)C1=CC=C([C@H]2[C@H](C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3Cl)C2)C=C1
Synonyms

trans-PX-102
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Arch Toxicol

Farnesoid X receptor (FXR) agonists induce hepatocellular apoptosis and impair hepatic functions via FXR/SHP pathway. [Abstract]

2022 Jun;96(6):1829-1843. PMID: 35267068
Biochem Pharmacol

Efficient screening and evaluation of MRGPRX2 antagonists based on AlphaFold 3. [Abstract]

2025 Oct 23:117451. PMID: 41138926
Biochem Pharmacol

FXR agonists for colorectal and liver cancers, as a stand-alone or in combination therapy. [Abstract]

2023 Jun:212:115570. PMID: 37119860

용액&용해도

In Vitro:

DMSO : 100 mg/mL (180.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8023 mL

9.0114 mL

18.0229 mL

5 mM

0.3605 mL

1.8023 mL

3.6046 mL

10 mM

0.1802 mL

0.9011 mL

1.8023 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8023 mL	9.0114 mL	18.0229 mL	45.0572 mL
	5 mM	0.3605 mL	1.8023 mL	3.6046 mL	9.0114 mL
	10 mM	0.1802 mL	0.9011 mL	1.8023 mL	4.5057 mL
	15 mM	0.1202 mL	0.6008 mL	1.2015 mL	3.0038 mL
	20 mM	0.0901 mL	0.4506 mL	0.9011 mL	2.2529 mL
	25 mM	0.0721 mL	0.3605 mL	0.7209 mL	1.8023 mL
	30 mM	0.0601 mL	0.3004 mL	0.6008 mL	1.5019 mL
	40 mM	0.0451 mL	0.2253 mL	0.4506 mL	1.1264 mL
	50 mM	0.0360 mL	0.1802 mL	0.3605 mL	0.9011 mL
	60 mM	0.0300 mL	0.1502 mL	0.3004 mL	0.7510 mL
	80 mM	0.0225 mL	0.1126 mL	0.2253 mL	0.5632 mL
	100 mM	0.0180 mL	0.0901 mL	0.1802 mL	0.4506 mL

Keywords

trans-PX20606

3 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (3)
용액&용해도
- In Vitro
순도&문서
References

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trans-PX20606

Metabolism/Protease Compound Library

Clinical Compound Library

Autophagy Compound Library

Nuclear Receptor Compound Library

Metabolic Enzyme Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) trans-PX20606

Biological Activity

Chemical Information

Publications (3)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

trans-PX20606

Metabolism/Protease Compound Library

Clinical Compound Library

Autophagy Compound Library

Nuclear Receptor Compound Library

Metabolic Enzyme Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) trans-PX20606

Biological Activity

Chemical Information

Publications (3)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

trans-PX20606 Related Classifications

HY-100443A Related Classifications