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Cat. No.: HY-P2074

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U 77436

U 77436 is a Renin inhibitory peptide. U 77436 is used in the research of hypertension.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 128657-36-3
화학식: C₅₀H₇₆N₁₀O₁₁
분자량:993.20

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

U 77436 Chemical Structure

CAS No.: 128657-36-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

U 77436 is a Renin inhibitory peptide. U 77436 is used in the research of hypertension^[1].

In Vivo

U 77436 (25 μg/rat; intratracheal administration) achieves an absorption rate of 52.1% in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, 400-550 g)^[1]
Dosage:

25 μg/rat (intrapulmonary); 75 μg/rat (intravenous)
Administration:

intrapulmonary; single dose; intravenous; single dose
Result:

Achieved total recovery of 104.9% in bile and urine after intravenous administration, with 93.3% recovered in bile and 11.6% recovered in urine.
Achieved total recovery of 53.7% in bile and urine after intrapulmonary administration, with 48.0% recovered in bile and 5.7% recovered in urine.
Reached 52.1% intrapulmonary absorption relative to intravenous recovery.
Showed 63% of ⁵¹Cr-labeled dose reached the lungs, with an estimated 81% of the lung-delivered dose absorbed by 10 hours.

Chemical Information

CAS No. 128657-36-3
분자량 993.20
화학식 C₅₀H₇₆N₁₀O₁₁
SMILES

[O-][N+]1=CC=CC=C1CNC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)C[C@H](O)[C@H](CC(C)C)NC([C@H](CC2=CN=CN2)N(C)C([C@H](CC3=CC=CC=C3)NC([C@H]4N(CCC4)C(NC(CO)(CO)CO)=O)=O)=O)=O)=O)=O
Sequence

{Pro(NHCO-NH-C(CH2OH)3)}-Phe-{His(NCH3)}-Leu{(CHOH-CH2)}-Val-{Ile(NHCH2-C5H4NO)}
Sequence Shortening

{Pro(NHCO‑NH‑C(CH2OH)3)}‑F‑{His(NCH3)}-Leu{(CHOH‑CH2)}-V-{Ile(NHCH2-C5H4NO)}
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Sheehy AM, et al. Intrapulmonary delivery of renin inhibitory peptides results in sustained release because of saturable transport. Pharm Res. 1993 Oct;10(10):1548-51. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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