UDP-GlcNAz
Based on 1 publication(s) in Google Scholar
UDP-GlcNAz is a UDP sugar. UDP-GlcNAz transfers GlcNAz to serine and threonine residues during O-GlcNAcylation and causes GlcNAz modification of substrate proteins (including recombinant mouse iNOS), which can be detected via Staudinger ligation with biotin-phosphine. UDP-GlcNAz provides a click chemistry handle through its azide group for the enrichment and fluorescence detection of O-GlcNAcylated proteins.
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- CAS No.: 608514-41-6
- 화학식: C17H26N6O17P2
- 분자량:648.37
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
제품 설명
In Vitro
UDP-GlcNAz (40 μM) is utilized by recombinant ncOGT as a substrate in the UDP-Glo assay, with UDP-4FGalNAz being accepted less efficiently than UDP-GlcNAz[2].
UDP-GlcNAz enables click-chemistry fluorescent detection with reduced background and identifies an asparagine ladder in the OGT TPR domain important for protein substrate binding in a cell-free protein microarray of ∼8,000 human proteins with purified OGT[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 608514-41-6
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분자량 648.37
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화학식 C17H26N6O17P2
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SMILES
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3NC(CN=[N+]=[N-])=O)(O)=O)(O)=O)O2)NC1=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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순도&문서
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UDP-GlcNAz Related Classifications
HY-145934B Related Classifications
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