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Cat. No.: HY-153731

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USP1-IN-4

USP1-IN-4 (compound 10) is an effective USP1 inhibitor with an IC₅₀ value of 2.44 nM. USP1-IN-4 has anticancer activity and synergistic activity with various anticancer drugs.

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CAS No.: 2878441-72-4
화학식: C₂₆H₂₃F₃N₆
분자량:476.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

USP1-IN-4 Chemical Structure

CAS No.: 2878441-72-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

USP1-IN-4 (compound 10) is an effective USP1 inhibitor with an IC₅₀ value of 2.44 nM. USP1-IN-4 has anticancer activity and synergistic activity with various anticancer drugs^[1].

IC₅₀ & Target

USP1

2.44 nM (IC₅₀)

All Deubiquitinase Isoforms :

In Vitro

USP1-IN-4 (0.0005-10 μM, 15 min) inhibits USP1/UAF1 significantly with an IC₅₀ value of 2.44 nM^[1].
USP1-IN-4 (0.0005-10 μM, 7 days) inhibits the growth of MDA-MB-436 significantly with an IC₅₀ value of 103.75 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MDA-MB-436
Concentration:

0.0005-10 μM
Incubation Time:

7 days
Result:

Inhibited cell growth with an IC₅₀ of 103.75 nM.

Chemical Information

CAS No. 2878441-72-4
분자량 476.50
화학식 C₂₆H₂₃F₃N₆
SMILES

FC(F)(C1=CN(C)C(C2=CC=C(CC3=NC=C4C=NC(C5=C(C(C)C)C=CC=C5)=NN43)C=C2)=N1)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cai S, et al. Nitrogen-containing fused heteroaromatic bicyclic compounds as USP1 inhibitors and the use thereof. China,WO 2022/253188 A.2022-8-12.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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수량:
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USP1-IN-4

All Deubiquitinase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

USP1-IN-4 Related Classifications

HY-153731 Related Classifications