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Cat. No.: HY-111636

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VSW1198

VSW1198 is an inhibitor for geranylgeranyl diphosphate synthase (GGDPS) with an IC₅₀ of 45 nM. VSW1198 reveals antitumor activity in myeloma- and prostate cancer with liver toxicity.

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화학식: C₁₅H₂₃N₃Na₄O₆P₂
분자량:495.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

VSW1198 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

VSW1198 is an inhibitor for geranylgeranyl diphosphate synthase (GGDPS) with an IC₅₀ of 45 nM. VSW1198 reveals antitumor activity in myeloma- and prostate cancer with liver toxicity^[1].

IC₅₀ & Target

IC₅₀: 45 nM (GGDPS)

Cellular Effect

Cell Line	Type	Value	Description	References
RPMI-8226	EC₅₀	0.19 μM Compound: 8	Cytotoxicity against human RPMI8226 after 48 hrs by MTT assay Cytotoxicity against human RPMI8226 after 48 hrs by MTT assay	[PMID: 26713103]

Chemical Information

분자량 495.27
화학식 C₁₅H₂₃N₃Na₄O₆P₂
SMILES

O=P(O[Na])(O[Na])C(P(O[Na])(O[Na])=O)CC1=CN(CC/C=C(C)/CC/C=C(C)/C)N=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Haney SL, Varney ML, Chhonker Y, Talmon G, Smith LM, Murry DJ, Holstein SA. In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway. Pharmacol Res. 2021 May;167:105528. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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