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Cat. No.: HY-119772

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VU0366369

Name: VU0366369
Brand: MedChemExpress
SKU: HY-119772
Price: 59.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ML137)

고객리뷰

Based on 1 Customer Validation

VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC₅₀ of 830 nM. VU0366369 can be used in research about central nervous system diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1222834-53-8
화학식: C₁₉H₁₄FN₃O₂
분자량:335.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

VU0366369 Chemical Structure

CAS No.: 1222834-53-8

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC₅₀ of 830 nM. VU0366369 can be used in research about central nervous system diseases^[1].

IC₅₀ & Target

EC₅₀: 830 nM (mAChR M1)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.83 μM Compound: 12a, VU0366369	Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay Potentiation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mobilization after 1 hr by FLIPR assay	[PMID: 20156687]
CHO-K1	EC₅₀	830 nM Compound: 2, ML 137	Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay Positive allosteric modulator activity at human muscarinic receptor subtype 1 expressed in CHO-K1 cells by calcium mobilization assay	[PMID: 25435150]

Chemical Information

CAS No. 1222834-53-8
분자량 335.33
화학식 C₁₉H₁₄FN₃O₂
SMILES

O=C1C(N(CC2=C(F)C=C(C3=CN(C)N=C3)C=C2)C4=C1C=CC=C4)=O
Synonyms

ML137
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bridges TM, et al., Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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VU0366369

All Cholinesterase (ChE) Isoforms