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Cat. No.: HY-184905

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W1507

W1507 is an NH₂-TML-based linker-payload conjugate, in which the payload is Exatecan (HY-13631) and the linker is Mal-PEG4-Val-Ala-Ph-2,2-dimethylpropanoic acid (HY-184906). W1507 can be conjugated with Trastuzumab (HY-P9907) to synthesize the ADC Her2-W1507. Her2-W1507 exhibits in vivo anti-tumor activity. W1507 can be used for the research of gastric cancer, ovarian adenocarcinoma and Her2-amplified breast cancer.

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화학식: C₆₁H₇₅FN₈O₁₅
분자량:1179.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

W1507 Chemical Structure

Amount: USD 0.00

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

W1507 (5 mM; 1 h) is resistant to cathepsin B-mediated cleavage, with no detectable Exatecan (HY-13631) release from the linker-payload in a cell-free in vitro assay^[1].
Her2-W1507 (72 h) potently inhibits the proliferation of HER2-positive NCI-N87, SK-OV-3, and SK-BR-3 cells with IC₅₀ values of 48.49 nM, 88.30 nM, and 65.22 nM respectively, while showing minimal activity against HER2-negative MDA-MB-231 cells (IC₅₀ >500 nM) after 72 hours of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 1179.29
화학식 C₆₁H₇₅FN₈O₁₅
SMILES

O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(NC1=CC=CC=C1CC(C)(C)C(N[C@H]2CCC3=C4C2=C(CN5C(C(COC([C@@]6(CC)O)=O)=C6C=C57)=O)C7=NC4=CC(F)=C3C)=O)=O)=O)CCOCCOCCOCCOCCNC(CCN8C(C=CC8=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Li X, et al. NH2-trimethyl lock (NH2-TML): a stable and effective adapter for exatecan-based antibody-drug conjugates. Bioorg Chem. 2026 Sep 5;179:110038. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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W1507

All Drug-Linker Conjugates for ADC Isoforms