WEE1-IN-14
WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor (IC50: 0.5 nM in L-RB-FEP calculations, 1.0 nM in ADP-Glo kinase assay). Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removes the regulatory controls on the cell cycle, and leads to early onset of mitotic failure followed by apoptosis of tumor cells. Therefore, WEE1-IN-14 is a useful tool for studying cancer biology.
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- CAS No.: 2803921-87-9
- 화학식: C25H25Cl2N7O
- 분자량:510.42
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2803921-87-9
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분자량 510.42
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화학식 C25H25Cl2N7O
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SMILES
O=C(N(C1=C(Cl)C=CC=C1Cl)CN2C)C3=C2C4=C(N=C3)NC(C5=CN(C6CCN(C)CC6)N=C5)=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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