Z56-L23
Z56-L23 is a conjugate of RAS-targeting ADC cytotoxic payload-linker with anti-tumor activity. Z56-L23 can be conjugated with HER3 antibody, EGFR antibody or EGFRxHER3 bispecific antibody to form intact antibody-drug conjugates (ADCs). ADC molecules related to Z56-L23 effectively inhibit the proliferation of tumor cells and also significantly suppress tumor growth in xenograft mouse models. Z56-L23 can be used in the research of pancreatic cancer.
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- CAS No.: 3077488-78-6
- 화학식: C98H136N15O22S+
- 분자량:1908.28
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보관:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Z56-L23 conjugated to HER3 antibody, EGFR antibody, or EGFRxHER3 bispecific antibody forms ADCs with high SEC monomer purity (97.70%-98.62%) and DAR values ranging from 4.17 to 7.93[1].
Z56-L23-HER3 ADC and Z56-L23-EGFR ADC potently inhibit the proliferation of NCI-H441 and AsPC-1 cells, with IC50 values ranging from 0.03 nM to 1.60 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice with Non-small cell lung cancer[1]
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Dosage:10 mg/kg (Z56-L23-HER3; Z56-L23-EGFR); 5 mg/kg (Z56-L23-EGFRxHER3)
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Administration:i.v.; qw ×2
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Result:Induced a tumor growth inhibition rate (TGI) of 99.15% and a mouse body weight change of 2.37% (Z56-L23-HER3).
Induced a TGI of 113.57% and a mouse body weight change of 8.38% (Z56-L23-EGFR).
Induced a TGI of 124.66% and a mouse body weight change of 1.24% (Z56-L23-EGFRxHER3).
Chemical Information
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CAS No. 3077488-78-6
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Appearance Solid
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분자량 1908.28
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화학식 C98H136N15O22S+
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Color White to off-white
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SMILES
O=C([C@H](CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)NC(CCN1C(C=CC1=O)=O)=O)NCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC2=CC=C(C[N+]3(CC#CC4=C[C@]([C@]5=C(CC(C)(COC([C@H]6NN7CCC6)=O)C)C8=C(C=CC(C9=CSC(C[C@@H](C7=O)NC([C@H]%10[C@H]%11[C@@H]%10COC%11)=O)=N9)=C8)N5CC)=C([C@@H](OC)C)N=C4)CCC(C#N)CC3)C=C2)=O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : 50 mg/mL (26.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5240 mL | 2.6202 mL | 5.2403 mL | 13.1008 mL |
| 5 mM | 0.1048 mL | 0.5240 mL | 1.0481 mL | 2.6202 mL | |
| 10 mM | 0.0524 mL | 0.2620 mL | 0.5240 mL | 1.3101 mL | |
| 15 mM | 0.0349 mL | 0.1747 mL | 0.3494 mL | 0.8734 mL | |
| 20 mM | 0.0262 mL | 0.1310 mL | 0.2620 mL | 0.6550 mL | |
| 25 mM | 0.0210 mL | 0.1048 mL | 0.2096 mL | 0.5240 mL |
Z56-L23 Related Classifications
HY-178836 Related Classifications
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