Kusunokinin
Based on 1 Customer Validation
Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis.
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- CAS No.: 58311-20-9
- Formule: C21H22O6
- Masse moléculaire:370.40
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
8.2 μM
Compound: 36
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Cytotoxicity against Spodoptera frugiperda Sf9 cells assessed as reduction in cell viability
Cytotoxicity against Spodoptera frugiperda Sf9 cells assessed as reduction in cell viability
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[PMID: 32359854] |
Kusunokinin ((-)-Kusunokinin; 0.625-10 µg/mL; 72 h) inhibits the viability of cancer cells with IC50 values of 3.08, 3.59, 3.98, 5.75, 5.77, 7.86 µM for MCF-7, HT-29, MDA-MB-468, SW-620, A-549, MDA-MB-231 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cancer cells
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Concentration:0.625, 1.25, 2.5, 5 and 10 µg/mL
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Incubation Time:72 hours
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Result:Had anticancer activity and inhibited cancer cells growth.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Sprague Dawley rats (7 weeks of age)[1]
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Dosage:7 and 14 mg/kg
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Administration:Subcutaneous injection, 3 times a week for 2 weeks
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Result:Inhibited the mammary tumor growth and decreased tumor volume.
Down-regulated c-Src, Erk1/2 and PI3K proteins and decreased Akt proteins.
Inhibited downstream molecules in the cell cycle (c-Myc, E2f-1, CDK1 and cyclin B1) and metastasis (E-cadherin, MMP-2 and MMP-9).
Chemical Information
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CAS No. 58311-20-9
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Appearance Oil
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Masse moléculaire 370.40
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Formule C21H22O6
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SMILES
COC1=C(OC)C=C(C[C@H]2COC([C@@H]2CC3=CC4=C(OCO4)C=C3)=O)C=C1
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Synonyms
(-)-Kusunokinin
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kusunokinin Related Classifications
HY-N10798 Related Classifications
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