KY0418
KY0418 is a selective GPX4 inhibitor. KY0418 selectively and covalently modifies the selenocysteine residue of GPX4 and inhibits GPX4 activity. KY0418 induces ferroptosis and suppresses cell proliferation. KY0418 can be used for the study of ferroptosis and cancer.
For research use only. We do not sell to patients.
- CAS No.: 3024369-07-8
- Formula: C28H35F3N8O3
- Molecular Weight:588.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GPX4 |
KY0418 (E46) potently inhibits proliferation of 786-O cells with an IC50 ≤ 100 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3024369-07-8
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Molecular Weight 588.62
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Formula C28H35F3N8O3
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SMILES
O=C(N1C2=CC=C(N3C[C@H](C)O[C@H](C)C3)N=C2)C4(CCCC4)C5=C1N=C(COC(N6[C@@H](C(F)(F)F)CCC6)=N)N=C5N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KY0418 Related Classifications
HY-186143 Related Classifications
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