2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase Ferroptosis
  4. KY0418

KY0418 is a selective GPX4 inhibitor. KY0418 selectively and covalently modifies the selenocysteine residue of GPX4 and inhibits GPX4 activity. KY0418 induces ferroptosis and suppresses cell proliferation. KY0418 can be used for the study of ferroptosis and cancer.

For research use only. We do not sell to patients.

KY0418

KY0418 Chemical Structure

CAS No. : 3024369-07-8

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KY0418 Related Antibodies

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Description

KY0418 is a selective GPX4 inhibitor. KY0418 selectively and covalently modifies the selenocysteine residue of GPX4 and inhibits GPX4 activity. KY0418 induces ferroptosis and suppresses cell proliferation. KY0418 can be used for the study of ferroptosis and cancer[1].

IC50 & Target[1]

GPX4

 

In Vitro

KY0418 (E46) potently inhibits proliferation of 786-O cells with an IC50 ≤ 100 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KY0418 Related Antibodies
Molecular Weight

588.62

Formula

C28H35F3N8O3
CAS No.
SMILES

O=C(N1C2=CC=C(N3C[C@H](C)O[C@H](C)C3)N=C2)C4(CCCC4)C5=C1N=C(COC(N6[C@@H](C(F)(F)F)CCC6)=N)N=C5N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KY0418 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY04183024369-07-8KY 0418KY-0418Glutathione PeroxidaseFerroptosis786-O cellsferroptosiscancercancer cell proliferationInhibitorinhibitorinhibit

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