L-2-Hydroxyglutaric acid disodium
Based on 1 Customer Validation
L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.
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- Reinheit : 99.93%
- CAS. Nr.: 63512-50-5
- Formel: C5H6Na2O5
- Molecular Weight:192.08
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
Chemical Information
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CAS. Nr. 63512-50-5
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Appearance Solid
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Molecular Weight 192.08
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Formel C5H6Na2O5
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Color White to off-white
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SMILES
O=C(O[Na])[C@@H](O)CCC(O[Na])=O
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Synonyms
(S)-2-Hydroxyglutaric acid disodium
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 83.33 mg/mL (433.83 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (130.15 mM); Clear solution; Need ultrasonic and warming
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8. [Content Brief]
[2]. da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.2062 mL | 26.0308 mL | 52.0616 mL | 130.1541 mL |
| 5 mM | 1.0412 mL | 5.2062 mL | 10.4123 mL | 26.0308 mL | |
| 10 mM | 0.5206 mL | 2.6031 mL | 5.2062 mL | 13.0154 mL | |
| 15 mM | 0.3471 mL | 1.7354 mL | 3.4708 mL | 8.6769 mL | |
| 20 mM | 0.2603 mL | 1.3015 mL | 2.6031 mL | 6.5077 mL | |
| 25 mM | 0.2082 mL | 1.0412 mL | 2.0825 mL | 5.2062 mL | |
| 30 mM | 0.1735 mL | 0.8677 mL | 1.7354 mL | 4.3385 mL | |
| 40 mM | 0.1302 mL | 0.6508 mL | 1.3015 mL | 3.2539 mL | |
| 50 mM | 0.1041 mL | 0.5206 mL | 1.0412 mL | 2.6031 mL | |
| 60 mM | 0.0868 mL | 0.4338 mL | 0.8677 mL | 2.1692 mL | |
| 80 mM | 0.0651 mL | 0.3254 mL | 0.6508 mL | 1.6269 mL | |
| 100 mM | 0.0521 mL | 0.2603 mL | 0.5206 mL | 1.3015 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-2-Hydroxyglutaric acid disodium Related Classifications
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