Labetuzumab
Based on 1 Customer Validation
Labetuzumab is a humanised anti-carcinoembryonic antigen (CEA) monoclonal antibody that inhibits tumour growth and sensitises human medullary thyroid cancer xenografts to Dacarbazine chemotherapy.
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 219649-07-7
- Molecular Weight:145.48 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1(K214R) kappa
Human
CEACAM5/CEA/CD66e
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female nu/nu mice (6 to 8-week-old; inject TT cells)[1].
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Dosage:0.5 mg/rat
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Administration:Intravenous injection; single (1 day post-tumor cell injection)
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Result:Significantly delaied growth of tumor, and led to 64%-70% inhibition of tumor size between days 32 and 60.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized CEACAM5 Protein, Human can bind Labetuzumab. The EC50 for this effect is 11.79 ng/mL. -
Flow cytometric analysis of 1X106 MCF-7 cells with Labetuzumab (HY-P99160, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 219649-07-7
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Appearance Liquid
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Molecular Weight 145.48 kDa
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Color Colorless to light yellow
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SMILES
[Labetuzumab]
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Synonyms
hMN14
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)