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Cat. No.: HY-N3401

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Lasiodiplodin

Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens.

For research use only. We do not sell to patients.

CAS No.: 32885-81-7

Formula: C₁₇H₂₄O₄

Molecular Weight:292.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Lasiodiplodin Chemical Structure

CAS No.: 32885-81-7

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Data Sheet (267 KB)

Handling Instructions (2659 KB)

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Biological Activity

Chemical Information

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References

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

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Classifications

Bioz

Biological Activity

Description

Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens^[1].

Cellular Effect

Cell Line

Type Value Description References

BV-2 IC₅₀
>100 μM
Compound: 10

Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated for 1 hr before LPS stimulation measured after 24 hrs by Griess assay

Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated for 1 hr before LPS stimulation measured after 24 hrs by Griess assay
[PMID: 27592135]

U-937 IC₅₀
20 μM
Compound: 32, lasiodiplodin

Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay

Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
[PMID: 17158054]

U-937 IC₅₀
28 μM
Compound: 32, lasiodiplodin

Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay

Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
[PMID: 17158054]

U-937 IC₅₀
36 μM
Compound: 32, lasiodiplodin

Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay

Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
[PMID: 17158054]

Chemical Information

CAS No. 32885-81-7

Molecular Weight 292.37

Formula C₁₇H₂₄O₄

SMILES

COC1=C2C(CCCCCCC[C@@H](OC2=O)C)=CC(O)=C1

Structure Classification

Others

Initial Source

Microorganisms

endophytic fungus

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. Leet K H, et al. Lasiodiplodin, a potent antileukemic macrolide from Euphorbia splendens[J]. Phytochemistry, 1982, 21(5): 1119-1121.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Lasiodiplodin Related Classifications

HY-N3401 Related Classifications

Disease Areas

Cancer

Natural Products

Microorganisms Others

Reference Standards

Natural Product Standards

Others

Cancer

Cancer Metabolism and Metastasis

Powered by Bioz See more details on Bioz

Keywords

Lasiodiplodin
32885-81-7
Others
anti-leukemic
Inhibitor
inhibitor
inhibit

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Cell Line	Type	Value	Description	References
BV-2	IC₅₀	>100 μM Compound: 10	Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated for 1 hr before LPS stimulation measured after 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated for 1 hr before LPS stimulation measured after 24 hrs by Griess assay	[PMID: 27592135]
U-937	IC₅₀	20 μM Compound: 32, lasiodiplodin	Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay	[PMID: 17158054]
U-937	IC₅₀	28 μM Compound: 32, lasiodiplodin	Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay	[PMID: 17158054]
U-937	IC₅₀	36 μM Compound: 32, lasiodiplodin	Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay	[PMID: 17158054]

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