Latarcibart  (Synonyms: VGA-039)

Latarcibart is an anti-protein S monoclonal antibody.Latarcibart can be used for the research of bleeding disorders^[1].

Human IgG4 kappa

Human IgG4 (S228P) kappa, Isotype Control

Human

Protein S/PROS1

Protein S is an important natural anticoagulant protein in the blood. As a cofactor of activated protein C, it jointly inactivates coagulation factors Va and VIIIa, thereby inhibiting the coagulation cascade and preventing excessive thrombosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5627  [NCBI]

P07225

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

3036400-21-9

Liquid

Colorless to light yellow

N/A

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  IgG4-kappa

• 
  Flow cytometric analysis of 1.5×10⁶ HepG2 cells labeling Latarcibart (HY-P991694, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

• [1]. Walker G, Sridevi M. American Society of Hematology-64th Annual Meeting and Exposition. New Orleans-December 10-13, 2022. Drugs of the Future. 2023;48(3).