Cationic Lipids & Ionizable Lipids

Lipid HTO12 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid HTO12 is a carrier for both siRNA and mRNA.

G1-OC2-K3-E10 is an ionizable lipid, and can be used for delivery of mRNA in lipid nanoparticles (LNPs).

DORI is a cationic lipid that can deliver plasmid DNA in vitro. DORI has lower cytotoxicity and high transfection efficiency.

Lipid AX4 is an ionizable cationic lipid that can be used to construct lipid nanoparticles (LNPs) for in vivo delivery of nucleic acids (e.g., mRNA, circRNA).

Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

113-O16B is a disulfide bond-containing ionizable cationic lipidoid. 113-O16B has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA.

LNP Lipid-26 can be applied in the generation of lipid nanoparticles (LNPs).

Lipid 20b is a thiophene ionizable cationic lipid. Lipid 20 b can be used to generate lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Lipid 20b can be studied in research for enhancing mRNA vaccine delivery and transfection efficacy.

L202 is an ionizable cationic lipid (pKa=6.04) that can be used for the study of mRNA and lipid nanoparticles.

VL-422 is an ionizable cationic lipid. VL-422 delivers CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA to enable in vitro and in vivo gene editing. LNPs containing VL-422 loaded with Cas9 mRNA and sgRNA targeting the ANGPTL3 gene induce the deletion of premature stop codons within the ANGPTL3 gene in the liver of cynomolgus monkeys. Loss-of-function of ANGPTL3 leads to decreased levels of LDL, HDL and cholesterol in plasma. The VL-422 delivery system can be used for the research of gene editing strategies targeting lipid metabolism diseases.

Docosahexaenoyl-L-carnitine chloride is a long-chain acylcarnitine composed of Docosahexaenoic acid (HY-B2167) and L-carnitine (HY-B0399). Docosahexaenoyl-L-carnitine chloride is transported into mitochondria for β -oxidation and decomposition under the action of carnitine palmitoyltransferase I (CPT I) and others. Docosahexaenoyl-L-carnitine chloride is promising for research of diseases related to fatty acid metabolism.

Lipid 23 is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNP). Lipid 23 can be used for mRNA delivery.

C3-K2-E14 is a multi-ionizable amino-lipid featuring a central tertiary amine with two identical branches and an n-propyl group. Each branch features a propanamide linking to a branched amine, each with two C14 arms and a hydroxyl. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug discovery.

C14-O2 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads.

Lipid 88 is an ionizable cationic lipid. Lipid 88 can be used to synthesize lipid nanoparticles and deliver mRNA.

PPPDA-O16B is a lipid containing disulfide bonds used for DNA delivery. PPPDA-O16B can encapsulate DNA plasmid, releasing DNA selectively via lipid degradation catalyzed by GSH.

Q1-SM-102 iodide is a quaternary ammonium lipid derivative of SM-102 (HY-13454). Q1-SM-102 iodide can be used to prepare lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Q1-SM-102 iodide is a carriers for targeting delivery of mRNA to immune organs.

AMG 1541 is a degradable ionizable lipid. AMG 1541 mediates the delivery of polynucleotides including mRNA. AMG 1541 exerts potent neutralizing effects on pseudotyped lentiviruses carrying the B.1.617.2 spike protein. As a component of influenza vaccines, AMG 1541 enables robust immune activation and reduces vaccine dosage. AMG 1541 is applicable to research related to SARS-CoV-2 infection.

Lipid PPz-2R1 is a lung-targeted lipid. Lipid PPz-2R1 is formulated into lipid nanoparticles (LNPs) for mRNA delivery. Lipid PPz-2R1 can be used for in situ lung cancer research.

Lipid 12T-O14 is a lipid nanoparticle. 12T-O14 facilitates local mRNA vaccine and systemic mRNA agent delivery.