Polyketides

Glycyrrhiza-flavonol A (compound 4) is a natural product of Glycyrrhiza, Fabaceae.

2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro.

Hesperetin 5-β-D-glucopyranoside is a flavonoid component, that can be isolated from Prunus davidiana.

Eupalitin, flavonol, is an active natural product. Eupalitin can be isolated from Eupatorium ligustrinum D.C.

Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 M_pro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS).

Lonchocarpic acid has an anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation.

4,2'-Dihydroxy-4'-methoxychalcone, a chalcone, shows allergy-preventive effects.

Mearnsitrin (compound 8) is a flavonol that can be isolated from methanolic extract Myrcia multiflora DC.

Quercetin-3,4-di-O-glucoside is a flavonoid that can be isolated from Allium cepa.

Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms.

(-)-Glycinol is a natural product that can be isolated from the roots of Pueraria Iobata.

Lupalbigenin is a natural compound with anti-metastatic and pro-apoptotic effects.

Phaseollidin is an antifungal agent that can be isolated from Phaseolus vulgaris L..

Sideritoflavone is a flavonoid. Sideritoflavone can be isolated from Baccharis densiflora. Sideritoflavone is toxic to JIMT-1 breast cancer cells.

2′-O-Methylphloretin (compound 3) is a flavonoid derivative. 2′-O-Methylphloretin can be isolated from the leaves of Melodorum siamensis. 2′-O-Methylphloretin inhibits the tumor cell line replication.

Parthenosin (Quercetin 3-O-β-D-glucuronide butyl ester) is a flavonoid, that can be isolated from the aerial parts of Calligoum polygonoides. Parthenosin shows cytotoxic activity against HepG2 and MCF-7 cell lines with IC₅₀ values of 60.46 and 61.4 μg/mL, respectively.

Cytochalasin N is a cytorelaxin derived from endophytic fungus Phomopsis sp.CIB-109.

6a,12a-Dehydro-α-toxicarol is a natural product that can be isolated from Amorpha fruticosa.

Methyllinderone is an inhibitor of AP-1/STAT/ERK. Methyllinderone has anti-inflammatory effect. Methyllinderone reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Methyllinderone can be used in study breast cancer metastasis.

Patulitrin has scavenging effect in the DPPH radical. Patulitrin inhibits soybean lipoxygenase. Patulitrin also has antihypertensive effect. Patulitrin is an antioxidant flavonoid that can be isolated from Anthemis tinctoria.