Sphingolipids

1-Deoxyceramide (m18:1/20:0) is a type of ceramide. 1-Deoxyceramide (m18:1/20:0) is upregulated in the dorsal root ganglia of mice treated with Docetaxel (HY-B0011).

C6 Biotin ganglioside gm3 (d18:1/6:0) (Biotin-C6:0-gm3) ammonium is a derivative of ganglioside GM3. C6 Biotin ganglioside gm3 (d18:1/6:0) ammonium can be used to detect or immobilize ganglioside GM3 through interaction with the biotin ligand.

C24 Ceramide (d18:1(14Z)/24:0) is a ceramide. C24 Ceramide (d18:1(14Z)/24:0) can be used in the research of obesity.

Cer(d18:2_22:0) is a potential biomarker for Metachromatic Leukodystrophy.

Globotriaosylceramide (non-hydroxy) (porcine RBC) is a glycosphingolipid found in the cell membranes of mammals. Globotriaosylceramide (non-hydroxy) (porcine RBC) is the core pathogenic molecule of Fabry disease, and its level can be downregulated by supplementing α-galactosidase A. Globotriaosylceramide (non-hydroxy) (porcine RBC) amplifies B-cell receptor signals by regulating the localization of co-receptor CD19, and can be used as a vaccine adjuvant, capable of guiding the generation of broad-spectrum and cross-protective antibody responses. Globotriaosylceramide (non-hydroxy) (porcine RBC) promotes wound healing and reduces scar formation by regulating fibroblast heterogeneity.

Sphingosine-1-phosphate (d18:1(14Z)) is an atypical sphingolipid that has a cis double bond at the 14-15 position. Sphingosine-1-phosphate is a critical regulator of various physiological and pathophysiological processes, such as cancer, atherosclerosis, diabetes and osteroporosis. Sphingosine-1-phosphate can be studied in research for inflammatory diseases, cancer and Alzheimer’s disease.

N,N-Dihexyl sphingosine (d18:1/6:0/6:0) (N,N-Dihexyl-D-erythro-sphingosine) is a synthetic analog of C18-Ceramide (HY-100355).

EOS (d18:1/30:0/18:2) is a kind ceramide in the outer epidermis.

C24:1 Ganglioside GM1 (d18:1/24:1) (ammonium) is a monosialylated ganglioside that contains nervonic acid.

C24:1 Ganglioside GM1 (d18:1/24:1) (C24:1-GM1) is a monosialylated ganglioside that contains nervonic acid.

C24:1 Ganglioside GM2 (d18:1/24:1) (C24:1-GM2) is a monosialylated ganglioside that contains nervonic acid.

C8 D-threo Ceramide (d18:1/8:0) is a sphingolipid analog that can effectively induce apoptosis in U937 cells and cause fragmentation of nucleosomal DNA.

C6-Phytoceramide is a cell-permeable analog of Phytoceramide. C6-Phytoceramide induces higher levels of apoptosis than C6-Ceramide (HY-19542) in neuroblastoma cells.

α-GalCer analog 8 is a triazole derivative of α-Galactosylceramide (HY-102022). α-Galactosylceramide is a synthetic glycolipid with antitumorial and immunostimulatory.

GT3 Sphingosine (d18:1) is a ganglioside.

C24:1 Ganglioside GM2 (d18:1/24:1) (ammonium) is an endogenous monosialylated ganglioside. C24:1 Ganglioside GM2 (d18:1/24:1) (ammonium) is a self-lipid that can bind to CD1d in HEK293T cells.

Gb3(d₁₈:1/16:0)-d₉ is deuterium labeled Gb3(d18:1/16:0) (HY-156209). Gb3 (d18:1/16:0) (Compound 1) is the P^k antigen of the P blood group system. Gb3 (d18:1/16:0) acts as a cell surface receptor. Gb3 (d18:1/16:0) is used for research on Burkitt's lymphoma, teratocarcinoma, embryonal carcinoma, and Fabry's disease.

C22 Galactosylceramide-d₄ is deuterium labeled C22 Galactosylceramide. C22 Galactosylceramide is a sphingolipid present in the central nervous system, exhibiting elevated levels in the spinal cord of mice on a methionine-restricted diet, while not affecting the brain or liver; furthermore, it has been identified in the postmortem hippocampus of Alzheimer's disease patients.

C24 (2'(R)-Hydroxy) dihydro ceramide (d18:0/24:0) ((R)-2'-Hydroxy cer(d18:0/24:0)) is the 2R-isomer of a 2’-hydroxylated form of C24 Dihydro ceramide (d18:0/24:0) (HY-156206).

C18:0-d₇ GD2 Ceramide (d₁₈:1/18:0-d₇) is deuterium labeled C18:0 GD2 Ceramide (d18:1/18:0).