Lithium dodecyl sulfate
Based on 1 Customer Validation
Lithium dodecyl sulfate is an anionic hydrocarbon surfactant with both surface tension reduction and interfacial adsorption capabilities. Lithium dodecyl sulfate forms micelles in aqueous solutions via entropy-driven (low temperature) and enthalpy-driven (high temperature) mechanisms, and can also form an adsorption layer at the air-water interface with quantifiable surface excess and minimum area per molecule. Lithium dodecyl sulfate exhibits favorable equilibrium surface tension and foamability, but shows low foam stability above its critical micelle concentration. When acting synergistically with tetrabutylammonium bromide, Lithium dodecyl sulfate also exhibits unique cloud point behavior due to micelle aggregation and phase separation.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2044-56-6
- Formula: C12H25LiO4S
- Molecular Weight:272.33
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Lithium dodecyl sulfate (1-50 mM) has the lowest foam stability among tested dodecyl sulfate counterion variants, measuring 10 min at 1 mM (below cmc) and ~20 min at 25 mM (above cmc), due to labile micelles that do not enhance foam stabilization[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2044-56-6
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Appearance Solid
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Molecular Weight 272.33
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Formula C12H25LiO4S
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Color White to off-white
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SMILES
CCCCCCCCCCCCOS(=O)(O[Li])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (367.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (183.60 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.18 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (767 KB)
- English - EN (767 KB)
- Français - FR (767 KB)
- Deutsch - DE (767 KB)
- Norwegian - NO (767 KB)
- Español - ES (767 KB)
- Swedish - SV (767 KB)
- Italian - IT (767 KB)
- Korean - KR (767 KB)
- Portuguese - PT (767 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.6720 mL | 18.3601 mL | 36.7202 mL | 91.8004 mL |
| 5 mM | 0.7344 mL | 3.6720 mL | 7.3440 mL | 18.3601 mL | |
| 10 mM | 0.3672 mL | 1.8360 mL | 3.6720 mL | 9.1800 mL | |
| 15 mM | 0.2448 mL | 1.2240 mL | 2.4480 mL | 6.1200 mL | |
| 20 mM | 0.1836 mL | 0.9180 mL | 1.8360 mL | 4.5900 mL | |
| 25 mM | 0.1469 mL | 0.7344 mL | 1.4688 mL | 3.6720 mL | |
| 30 mM | 0.1224 mL | 0.6120 mL | 1.2240 mL | 3.0600 mL | |
| 40 mM | 0.0918 mL | 0.4590 mL | 0.9180 mL | 2.2950 mL | |
| 50 mM | 0.0734 mL | 0.3672 mL | 0.7344 mL | 1.8360 mL | |
| 60 mM | 0.0612 mL | 0.3060 mL | 0.6120 mL | 1.5300 mL | |
| 80 mM | 0.0459 mL | 0.2295 mL | 0.4590 mL | 1.1475 mL | |
| 100 mM | 0.0367 mL | 0.1836 mL | 0.3672 mL | 0.9180 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lithium dodecyl sulfate Related Classifications
HY-W099535 Related Classifications
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