LTA4H-IN-4
LTA4H-IN-4 (compound 3) is an orally active LTA4H inhibitor. The IC50 value of LTA4H-IN-4 for hERG is 156 μM. LTA4H-IN-4 can be used in inflammation related studies.
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- No. CAS: 3034839-03-4
- Fòrmula: C19H21N5O2
- Peso molecular:351.40
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Descripciòn
IC50 & Target
|
LTA4H |
hERG 156 μM (IC50) |
In Vitro
LTA4H-IN-4 (compound 3) (0-10 μM, 4 h) completely inhibits LTB4 release in primary peripheral blood mononuclear cells (PBMCs) following calcium ionophore stimulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Pharmacokinetic Analysis in mice rats and dogs[1]
| Animal model | Route | Dose (mg/kg) | CL (mL/min kg) | Vss (L/kg) | MRT (h) | AUCp.o. d.n.(nM·h) | Cmax d.n. (nM) | BAV (%) |
| mice | i.v. | 1 | 13 | 7.2 | 8.9 | / | / | / |
| mice | p.o. | 10 | / | / | / | 1476 | 307 | 42 |
| rats | i.v. | 1 | 21 | 6.3 | 5.0 | / | / | / |
| rats | p.o. | 3 | / | / | / | 2200 | 175 | 97 |
| rats | p.o. | 30 | / | / | / | 1773 | 198 | 78 |
| rats | p.o. | 300 | / | / | / | 1741 | 87 | 77 |
| dogs | i.v. | 0.1 | 6.6 | 13 | 20 | / | / | / |
| dogs | p.o. | 0.1 | / | / | / | 6020 | 610 | 86 |
| dogs | p.o. | 1 | / | / | / | 6655 | 859 | 95 |
| dogs | p.o. | 10 | / | / | / | 7113 | 1157 | 102 |