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Cat. No.: HY-183416

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M&B 39279

M&B 39279 is an inhibitor of protoporphyrinogen oxidase (Protoporphyrinogen Oxidase). M&B 39279 induces protoporphyrin IX accumulation, light-dependent lipid peroxidation, degradation of membranes and organelles, and reduction of photosynthesis. M&B 39279 functions through the mechanism of action of diphenyl ether herbicides, and can be used for studies on PPO inhibition and herbicide mechanisms of action.

For research use only. We do not sell to patients.

CAS No.: 111234-77-6
Formula: C₁₁H₅Cl₂F₃N₄
Molecular Weight:321.09

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Please store the product under the recommended conditions in the Certificate of Analysis.

M&B 39279 Chemical Structure

CAS No.: 111234-77-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
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Biological Activity

Description

In Vitro

Mitochondrial FunctionMitochondrial Oxidative PhosphorylationOxidative Stress

Mitochondrial Function

Mitochondrial Oxidative Phosphorylation

M&B 39279 inhibits protoporphyrinogen oxidase in membranes of potato tuber mitochondria, maize etioplasts, mouse liver mitochondria and yeast mitochondria, with IC₅₀ values of 15 nM, 80 nM, 0.5 μM and 3 μM, respectively^[1].

Oxidative Stress

M&B 39279 (100 μM; 3-30 hr light, 30 hr darkness) induces light-dependent diphenyl ether-type phytotoxicity in detached Galium aparine leaves. After treatment with 100 μM under 50 μmol m^-2 sec^-1 light for 3 hours, chloroplast envelope damage appears first, followed by progressive degradation of membranes and organelles, rapid loss of photosynthetic capacity, delayed chlorophyll degradation, and membrane leakage associated with lipid peroxidation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Ferroptosis Solutions

Chemical Information

CAS No. 111234-77-6
Molecular Weight 321.09
Formula C₁₁H₅Cl₂F₃N₄
SMILES

N#CC1=CN(C2=C(C=C(C(F)(F)F)C=C2Cl)Cl)N=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matringe M et al. Protoporphyrinogen oxidase inhibition by three peroxidizing herbicides: oxadiazon, LS 82-556 and M&B 39279. FEBS Lett. 1989 Mar 13;245(1-2):35-38. [Content Brief]

[2]. Derrick PM, et al. Ultrastructural effects of the diphenyl ether herbicide acifluorfen and the experimental herbicide M&B 39279. Pestic Biochem Physiol. 1988;32:153-163.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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