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  2. PROTAC Linker
  3. m-PEG3-aldehyde

m-PEG3-aldehyde 

Cat. No.: HY-124011
Handling Instructions

m-PEG3-aldehyde is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG3-aldehyde Chemical Structure

m-PEG3-aldehyde Chemical Structure

CAS No. : 356066-46-1

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Description

m-PEG3-aldehyde is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
The binding affinities of anti-mPEGs depend more on the backbone lengths of the polymers and the hydrophobicities of their end-groups than on their resemblance to the methoxy terminus of the immunogenic polymer[1].
Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG spacer increases solubility in aqueous media.

Molecular Weight

176.21

Formula

C₈H₁₆O₄

CAS No.

356066-46-1

SMILES

O=CCCOCCOCCOC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

m-PEG3-aldehydePROTAC LinkermPEGPROTAClinkerInhibitorinhibitorinhibit

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m-PEG3-aldehyde
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HY-124011
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