1. PROTAC
  2. PROTAC Linkers
  3. m-PEG4-SH

m-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG4-SH Chemical Structure

m-PEG4-SH Chemical Structure

CAS No. : 52190-55-3

Size Price Stock Quantity
5 mg USD 27 In-stock
10 mg USD 38 In-stock
50 mg USD 75 In-stock
100 mg USD 120 In-stock
250 mg USD 200 In-stock
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

m-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

224.32

Formula

C9H20O4S

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCS

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (445.79 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4579 mL 22.2896 mL 44.5792 mL
5 mM 0.8916 mL 4.4579 mL 8.9158 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4579 mL 22.2896 mL 44.5792 mL 111.4479 mL
5 mM 0.8916 mL 4.4579 mL 8.9158 mL 22.2896 mL
10 mM 0.4458 mL 2.2290 mL 4.4579 mL 11.1448 mL
15 mM 0.2972 mL 1.4860 mL 2.9719 mL 7.4299 mL
20 mM 0.2229 mL 1.1145 mL 2.2290 mL 5.5724 mL
25 mM 0.1783 mL 0.8916 mL 1.7832 mL 4.4579 mL
30 mM 0.1486 mL 0.7430 mL 1.4860 mL 3.7149 mL
40 mM 0.1114 mL 0.5572 mL 1.1145 mL 2.7862 mL
50 mM 0.0892 mL 0.4458 mL 0.8916 mL 2.2290 mL
60 mM 0.0743 mL 0.3715 mL 0.7430 mL 1.8575 mL
80 mM 0.0557 mL 0.2786 mL 0.5572 mL 1.3931 mL
100 mM 0.0446 mL 0.2229 mL 0.4458 mL 1.1145 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

m-PEG4-SH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
m-PEG4-SH
Cat. No.:
HY-133271
Quantity:
MCE Japan Authorized Agent: