2. PROTAC
  3. PROTAC Linkers
  4. m-PEG5-SH

m-PEG5-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG5-SH Chemical Structure

m-PEG5-SH Chemical Structure

CAS No. : 524030-00-0

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50 mg USD 95 In-stock
100 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

m-PEG5-SH Related Antibodies

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Description

m-PEG5-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG5-SH Related Antibodies
Molecular Weight

268.37

Formula

C11H24O5S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCOCCS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (372.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7262 mL 18.6310 mL 37.2620 mL
5 mM 0.7452 mL 3.7262 mL 7.4524 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (238 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7262 mL 18.6310 mL 37.2620 mL 93.1550 mL
5 mM 0.7452 mL 3.7262 mL 7.4524 mL 18.6310 mL
10 mM 0.3726 mL 1.8631 mL 3.7262 mL 9.3155 mL
15 mM 0.2484 mL 1.2421 mL 2.4841 mL 6.2103 mL
20 mM 0.1863 mL 0.9315 mL 1.8631 mL 4.6577 mL
25 mM 0.1490 mL 0.7452 mL 1.4905 mL 3.7262 mL
30 mM 0.1242 mL 0.6210 mL 1.2421 mL 3.1052 mL
40 mM 0.0932 mL 0.4658 mL 0.9315 mL 2.3289 mL
50 mM 0.0745 mL 0.3726 mL 0.7452 mL 1.8631 mL
60 mM 0.0621 mL 0.3105 mL 0.6210 mL 1.5526 mL
80 mM 0.0466 mL 0.2329 mL 0.4658 mL 1.1644 mL
100 mM 0.0373 mL 0.1863 mL 0.3726 mL 0.9315 mL
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m-PEG5-SH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG5-SH524030-00-0PROTAC LinkersInhibitorinhibitorinhibit

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