2. Anti-infection
  3. Bacterial
  4. M4284

M4284 

Cat. No.: HY-120568 Purity: 98.15%
COA Handling Instructions

M4284 is a selective and orally active biphenyl mannoside FimH antagonist. M4284 has activities against different UPEC (Urinary tract infections (UTI) caused by uropathogenic E. coli) strains in different host genetic backgrounds and gut microbial community contexts.

For research use only. We do not sell to patients.

M4284 Chemical Structure

M4284 Chemical Structure

CAS No. : 1373346-85-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 347 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 347 In-stock
Solid
5 mg USD 343 In-stock
10 mg USD 550 In-stock
25 mg USD 1100 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

M4284 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

M4284 is a selective and orally active biphenyl mannoside FimH antagonist. M4284 has activities against different UPEC (Urinary tract infections (UTI) caused by uropathogenic E. coli) strains in different host genetic backgrounds and gut microbial community contexts[1].

IC50 & Target

IC50: FimH[1]
In Vivo

M4284 (oral administration; 100 mg/kg; 3 doses) can reduces UTI89 levels in the gut and urinary tracts of mice that are concurrently colonized with UTI89 in the gut and bladder. And treating mice with additonal M4284 doses further reduces the UTI89 population and the number of UPEC is lower in M4284-treated mice after termination of treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/HeN mice[1].
Dosage: 100 mg/kg
Administration: Oral administation; a single dose.
Result: Had activities against different UPEC strains in different host genetic backgrounds and gut microbial community contexts.
Molecular Weight

460.48

Appearance

Solid

Formula

C23H28N2O8
CAS No.
SMILES

O=C(C1=CC(C(NC)=O)=CC(C2=CC=C(O[C@@H]3[C@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(C)=C2)=C1)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (271.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1716 mL 10.8582 mL 21.7165 mL
5 mM 0.4343 mL 2.1716 mL 4.3433 mL
10 mM 0.2172 mL 1.0858 mL 2.1716 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (13.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (13.57 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.15%

COA (248 KB) HNMR (264 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References
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M4284 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

M42841373346-85-0M 4284M-4284BacterialUTIUPECE.CoilmannosideInhibitorinhibitorinhibit

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