1. Anti-infection
  2. Bacterial
  3. M4284

M4284 

Cat. No.: HY-120568
Handling Instructions

M4284 is a selective and orally active biphenyl mannoside FimH antagonist. M4284 has activities against different UPEC (Urinary tract infections (UTI) caused by uropathogenic E. coli) strains in different host genetic backgrounds and gut microbial community contexts.

For research use only. We do not sell to patients.

M4284 Chemical Structure

M4284 Chemical Structure

CAS No. : 1373346-85-0

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

M4284 is a selective and orally active biphenyl mannoside FimH antagonist. M4284 has activities against different UPEC (Urinary tract infections (UTI) caused by uropathogenic E. coli) strains in different host genetic backgrounds and gut microbial community contexts[1].

IC50 & Target

IC50: FimH[1]

In Vivo

M4284 (oral administration; 100 mg/kg; 3 doses) can reduces UTI89 levels in the gut and urinary tracts of mice that are concurrently colonized with UTI89 in the gut and bladder. And treating mice with additonal M4284 doses further reduces the UTI89 population and the number of UPEC is lower in M4284-treated mice after termination of treatment[1].

Animal Model: C3H/HeN mice[1].
Dosage: 100 mg/kg
Administration: Oral administation; a single dose.
Result: Had activities against different UPEC strains in different host genetic backgrounds and gut microbial community contexts.
Molecular Weight

460.48

Formula

C₂₃H₂₈N₂O₈

CAS No.

1373346-85-0

SMILES

O=C(C1=CC(C(NC)=O)=CC(C2=CC=C(O[[email protected]@H]3[[email protected]]([[email protected]]([[email protected]@H]([[email protected]@H](CO)O3)O)O)O)C(C)=C2)=C1)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

M4284M 4284M-4284BacterialUTIUPECE.CoilmannosideInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
M4284
Cat. No.:
HY-120568
Quantity:
MCE Japan Authorized Agent: