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Cat. No.: HY-161377

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M4K2306

M4K2306 is a selective inhibitor for activin receptor-like kinase-2 (ALK2) with an IC₅₀ of 7 nM. M4K2306 is blood brain permeable with a brain to plasma ratio of 75.6.

For research use only. We do not sell to patients.

CAS No.: 3034840-25-7
Formula: C₂₈H₃₄N₄O₃
Molecular Weight:474.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

M4K2306 Chemical Structure

CAS No.: 3034840-25-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

M4K2306 is a selective inhibitor for activin receptor-like kinase-2 (ALK2) with an IC₅₀ of 7 nM. M4K2306 is blood brain permeable with a brain to plasma ratio of 75.6^[1].

IC₅₀ & Target

ALK2

7 nM (IC₅₀)

ALK5

3915 nM (IC₅₀)

All TGF-β Receptor Isoforms :

In Vivo

M4K2306 (25 mg/kg, po, single dose) exhibits exposure in plasma concentration C_max of 254 and 17 mM, at 1 hour and 24 hour in NOD-SCID mice model, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034840-25-7
Molecular Weight 474.59
Formula C₂₈H₃₄N₄O₃
SMILES

CN1CC(C(C2=CC(OC)=C(C(OC)=C2)OC)=CN=C3)=C3C4=CC=C(N5CCN(CC5)C)C=C4C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. González-Álvarez H, et al., Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 28;67(6):4707-4725. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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