Macarangin
Macarangin can be isolated from propolis. Macarangin has DPPH radical-scavenging activity and shows anti-inflammatory activities via inhibiting the activation process of NLRP3 inflammasome.
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- CAS 番号: 129385-65-5
- 分子式: C25H26O6
- 分子量:422.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>0.0001 x 10-5M
Compound: 23
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Cytotoxicity against human A549 cells after 72 hrs by XTT assay
Cytotoxicity against human A549 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HeLa | IC50 |
>0.0001 x 10-5M
Compound: 23
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Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| HT-29 | IC50 |
>0.0001 x 10-5M
Compound: 23
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Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay
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[PMID: 20619940] |
| NCI-H460 | IC50 |
5.7 μM
Compound: 5
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Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin C
Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin C
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[PMID: 21275386] |
化学情報
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CAS 番号 129385-65-5
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分子量 422.47
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分子式 C25H26O6
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SMILES
OC1=C(C2=CC=C(O)C=C2)OC3=CC(O)=C(C/C=C(C)/CC/C=C(C)/C)C(O)=C3C1=O
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Structure Classification
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Initial Source
Kenyan propolis
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Petrova A, et al. New biologically active compounds from Kenyan propolis. Fitoterapia. 2010;81(6):509-514. [Content Brief]
[2]. Hu Y, et al. Total synthesis/semi-synthesis of natural isopentenyl flavonoids with inhibitory activity on NLRP3 inflammasome. Bioorg Med Chem Lett. 2024;107:129777. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Macarangin 関連分類
HY-N12941 関連分類
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