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Cat. No.: HY-182972

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Mal-PEG4-NPV-PABC-DMEDA-tofacitinib

Mal-PEG4-NPV-PABC-DMEDA-tofacitinib is a conjugate of a toxin and a linker, consisting of the JAK inhibitor Tofacitinib (HY-40354) and the linker Mal-PEG4-NPV-PABC-DMEDA (HY-182977). Mal-PEG4-NPV-PABC-DMEDA-tofacitinib can be used for the synthesis of ADC molecules.

For research use only. We do not sell to patients.

CAS No.: 3110422-32-4
Formula: C₅₈H₈₀N₁₄O₁₅
Molecular Weight:1213.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mal-PEG4-NPV-PABC-DMEDA-tofacitinib Chemical Structure

CAS No.: 3110422-32-4

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Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

All JAK Isoforms :

Chemical Information

CAS No. 3110422-32-4
Molecular Weight 1213.34
Formula C₅₈H₈₀N₁₄O₁₅
SMILES

O=C(N1C2=NC=NC(N([C@@H](C3)[C@@H](CCN3C(CC#N)=O)C)C)=C2C=C1)N(CCN(C)C(OCC4=CC=C(NC([C@H](C(C)C)NC([C@@H]5CCCN5C([C@@H](NC(CCOCCOCCOCCOCCN6C(C=CC6=O)=O)=O)CC(N)=O)=O)=O)=O)C=C4)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Murray E, et al. A Rationally Designed Novel Bifunctional Human TNF-α- and Janus Kinase-Targeted soloMER Drug Conjugate (SDC) with a Neutrophil Elastase Cleavable Linker Delivering Inflammation Site-Specific Release of Payload. J Med Chem. 2026 Apr 7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Mal-PEG4-NPV-PABC-DMEDA-tofacitinib

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Mal-PEG4-NPV-PABC-DMEDA-tofacitinib

All Drug-Linker Conjugates for ADC Isoforms

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Mal-PEG4-NPV-PABC-DMEDA-tofacitinib Related Classifications

HY-182972 Related Classifications