MEISi-2
Based on 1 Customer Validation
MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer.
For research use only. We do not sell to patients.
- Purity: 98.97%
- CAS No.: 2250156-71-7
- Formula: C18H14N2O3
- Molecular Weight:306.32
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MEIS[1]
MEISi-2 does not significantly inhibit the PBX-Luc-reporter[1].
MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal[1].
MEISi-2 down-regulates MEIS target gene expression[1].
MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-6 week-old BALB/c mice[1]
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Dosage:10 µM/100 µL
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Administration:Intraperitoneal injection, at day 1, day 4 and day 7
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Result:Modulated HSC pool.
Chemical Information
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CAS No. 2250156-71-7
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Appearance Solid
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Molecular Weight 306.32
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Formula C18H14N2O3
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Color Light yellow to yellow
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SMILES
O=C(NN/C=C1C(C=CC2=C\1C=CC=C2)=O)C3=CC=C(O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (326.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2646 mL | 16.3228 mL | 32.6456 mL | 81.6140 mL |
| 5 mM | 0.6529 mL | 3.2646 mL | 6.5291 mL | 16.3228 mL | |
| 10 mM | 0.3265 mL | 1.6323 mL | 3.2646 mL | 8.1614 mL | |
| 15 mM | 0.2176 mL | 1.0882 mL | 2.1764 mL | 5.4409 mL | |
| 20 mM | 0.1632 mL | 0.8161 mL | 1.6323 mL | 4.0807 mL | |
| 25 mM | 0.1306 mL | 0.6529 mL | 1.3058 mL | 3.2646 mL | |
| 30 mM | 0.1088 mL | 0.5441 mL | 1.0882 mL | 2.7205 mL | |
| 40 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL | 2.0403 mL | |
| 50 mM | 0.0653 mL | 0.3265 mL | 0.6529 mL | 1.6323 mL | |
| 60 mM | 0.0544 mL | 0.2720 mL | 0.5441 mL | 1.3602 mL | |
| 80 mM | 0.0408 mL | 0.2040 mL | 0.4081 mL | 1.0202 mL | |
| 100 mM | 0.0326 mL | 0.1632 mL | 0.3265 mL | 0.8161 mL |
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