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MEISi-2 

Cat. No.: HY-134259
Handling Instructions

MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer.

For research use only. We do not sell to patients.

MEISi-2 Chemical Structure

MEISi-2 Chemical Structure

CAS No. : 2250156-71-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer[1].

IC50 & Target

MEIS[1]

In Vitro

MEISi-2 does not significantly inhibit the PBX-Luc-reporter[1].
MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal[1].
MEISi-2 down-regulates MEIS target gene expression[1].
MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MEISi-2 (10 µM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content[1].
MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 week-old BALB/c mice[1]
Dosage: 10 µM/100 µL
Administration: Intraperitoneal injection, at day 1, day 4 and day 7
Result: Modulated HSC pool.
Molecular Weight

306.32

Formula

C₁₈H₁₄N₂O₃

CAS No.
SMILES

O=C(NN/C=C1C(C=CC2=C\1C=CC=C2)=O)C3=CC=C(O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

MEISi-2MEISi2MEISi 2Othersmeis1TALEcardiacinjurieshematopoiesisissuesbonemarrowtransplantationscancerInhibitorinhibitorinhibit

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MEISi-2
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HY-134259
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