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MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer.

For research use only. We do not sell to patients.

MEISi-2 Chemical Structure

MEISi-2 Chemical Structure

CAS No. : 2250156-71-7

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Based on 1 publication(s) in Google Scholar

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Description

MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer[1].

IC50 & Target

MEIS[1]

In Vitro

MEISi-2 does not significantly inhibit the PBX-Luc-reporter[1].
MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal[1].
MEISi-2 down-regulates MEIS target gene expression[1].
MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MEISi-2 (10 µM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content[1].
MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-6 week-old BALB/c mice[1]
Dosage: 10 µM/100 µL
Administration: Intraperitoneal injection, at day 1, day 4 and day 7
Result: Modulated HSC pool.
Molecular Weight

306.32

Formula

C18H14N2O3

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NN/C=C1C(C=CC2=C\1C=CC=C2)=O)C3=CC=C(O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

H2O : < 0.1 mg/mL (insoluble)

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Purity & Documentation

Purity: 99.12%

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MEISi-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MEISi-2
Cat. No.:
HY-134259
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