Mesaconine

Cat. No.: HY-N1922 Purity: 99.08%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mesaconinean, an ingredient from Aconitum carmichaelii Debx., has cardiac effect.

For research use only. We do not sell to patients.

Mesaconine Chemical Structure

CAS No. : 6792-09-2

Size	Price	Stock	Quantity
1 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Description

Mesaconinean, an ingredient from Aconitum carmichaelii Debx., has cardiac effect^[1].

Molecular Weight

485.57

Formula

C₂₄H₃₉NO₉

CAS No.

6792-09-2

Appearance

Solid

Color

White to off-white

SMILES

CO[C@@H]1C(C(N(C)C2)C3[C@@H]4OC)([C@@](C[C@@]5(O)[C@@H]6O)([H])[C@@]6([H])[C@@]3([C@@H](O)[C@@H]5OC)O)[C@@]4([H])[C@@]2(COC)[C@H](O)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (205.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0594 mL	10.2972 mL	20.5944 mL
5 mM	0.4119 mL	2.0594 mL	4.1189 mL
10 mM	0.2059 mL	1.0297 mL	2.0594 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.08%

Select Batch:

Data Sheet (282 KB) SDS (251 KB)

COA (264 KB) HNMR (185 KB) CNMR (239 KB) RP-HPLC (190 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0594 mL	10.2972 mL	20.5944 mL	51.4859 mL
	5 mM	0.4119 mL	2.0594 mL	4.1189 mL	10.2972 mL
	10 mM	0.2059 mL	1.0297 mL	2.0594 mL	5.1486 mL
	15 mM	0.1373 mL	0.6865 mL	1.3730 mL	3.4324 mL
	20 mM	0.1030 mL	0.5149 mL	1.0297 mL	2.5743 mL
	25 mM	0.0824 mL	0.4119 mL	0.8238 mL	2.0594 mL
	30 mM	0.0686 mL	0.3432 mL	0.6865 mL	1.7162 mL
	40 mM	0.0515 mL	0.2574 mL	0.5149 mL	1.2871 mL
	50 mM	0.0412 mL	0.2059 mL	0.4119 mL	1.0297 mL
	60 mM	0.0343 mL	0.1716 mL	0.3432 mL	0.8581 mL
	80 mM	0.0257 mL	0.1287 mL	0.2574 mL	0.6436 mL
	100 mM	0.0206 mL	0.1030 mL	0.2059 mL	0.5149 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mesaconine6792-09-2Inhibitorinhibitorinhibit

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