Methyltetrazine-Ph-NHS ester

Name: Methyltetrazine-Ph-NHS ester
Brand: MedChemExpress
SKU: HY-130283
Rating: 4.5 (1 reviews)

Cat. No.: HY-130283 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

For research use only. We do not sell to patients.

Methyltetrazine-Ph-NHS ester Chemical Structure

CAS No. : 1644644-96-1

Size	Price	Stock	Quantity
25 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC₅₀ & Target

Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

327.29

Formula

C₁₅H₁₃N₅O₄

CAS No.

1644644-96-1

Appearance

Solid

Color

Purple to purplish red

SMILES

O=C(ON1C(CCC1=O)=O)CC2=CC=C(C3=NN=C(C)N=N3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (305.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0554 mL	15.2770 mL	30.5539 mL
5 mM	0.6111 mL	3.0554 mL	6.1108 mL
10 mM	0.3055 mL	1.5277 mL	3.0554 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (248 KB) HNMR (130 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0554 mL	15.2770 mL	30.5539 mL	76.3849 mL
	5 mM	0.6111 mL	3.0554 mL	6.1108 mL	15.2770 mL
	10 mM	0.3055 mL	1.5277 mL	3.0554 mL	7.6385 mL
	15 mM	0.2037 mL	1.0185 mL	2.0369 mL	5.0923 mL
	20 mM	0.1528 mL	0.7638 mL	1.5277 mL	3.8192 mL
	25 mM	0.1222 mL	0.6111 mL	1.2222 mL	3.0554 mL
	30 mM	0.1018 mL	0.5092 mL	1.0185 mL	2.5462 mL
	40 mM	0.0764 mL	0.3819 mL	0.7638 mL	1.9096 mL
	50 mM	0.0611 mL	0.3055 mL	0.6111 mL	1.5277 mL
	60 mM	0.0509 mL	0.2546 mL	0.5092 mL	1.2731 mL
	80 mM	0.0382 mL	0.1910 mL	0.3819 mL	0.9548 mL
	100 mM	0.0306 mL	0.1528 mL	0.3055 mL	0.7638 mL