MG-Lin3
MG-Lin3 is a Lin28 molecular glue degrader. MG-Lin3 recruits the E3 ubiquitin ligase RNF126 to form a ternary complex, induces the degradation of Lin28 via the ubiquitin-proteasome pathway, and restores the levels of mature let-7 miRNA. MG-Lin3 can be used in research on ovarian cancer, ovarian teratocarcinoma, and uterine cancer.
For research use only. We do not sell to patients.
- Formula: C30H30N6O4
- Molecular Weight:538.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MG-Lin3 (0.1-100 μM; 24 h) is a potent molecular glue degrader that promotes Lin28 degradation and restores let-7 activity in transfected PA-1 ovarian cancer cells, with a significant reduction in luciferase signal observed even at a concentration of 0.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 538.60
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Formula C30H30N6O4
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SMILES
COC1=CC=C(C=C1)C(/C=C/C(N2CCC(CC2)C(N(C3=CC=CC(C4=NN5C(C)=NN=C5C=C4)=C3)C)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MG-Lin3 Related Classifications
HY-177733 Related Classifications
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