Minimolide L
Minimolide L is a sesquiterpene lactone. Minimolide L can be isolated from the whole plant of Centipeda minima. Minimolide L does not inhibit nitric oxide production. Minimolide L exhibits no anticancer activity against liver cancer, colorectal cancer, and cervical cancer.
For research use only. We do not sell to patients.
- CAS No.: 2629213-38-1
- Formula: C21H30O6
- Molecular Weight:378.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
10 μM
Compound: 4
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 33533247] |
In Vitro
Minimolide L (0.19-40 μM; 48 h) is inactive against Hela, HCT-116, and HepG2 cells, with an IC50 >10 μM for all tested cell lines[1].
Minimolide L (0.066-50 μM; 24 h) is inactive against nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells, with an IC50 >10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Hela human cervical carcinoma cells, HCT-116 human colon carcinoma cells, HepG2 human liver hepatocellular carcinoma cells
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Concentration:0.19-40 μM
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Incubation Time:48 h
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Result:Exhibited no cytotoxic activity against Hela, HCT-116, and HepG2 cells, with an IC50 value greater than 10 μM for all three cell lines.
Chemical Information
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CAS No. 2629213-38-1
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Molecular Weight 378.47
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Formula C21H30O6
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SMILES
C[C@]12[C@@H](OC(/C(=C\C)/C)=O)[C@]3([C@@](C[C@@H](C)[C@@]1([C@H](OC)CC2=O)[H])(OC(=O)[C@H]3C)[H])[H]
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Minimolide L Related Classifications
HY-N19153 Related Classifications
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