Miro1 Reducer

Cat. No.: HY-163172: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Miro1 Reducer is a small molecule that can repair this defect of Miro1 in Parkinson's disease (PD) fibroblasts. Miro1 Reducer reduces the delayed mitophagy phenotype in PD fibroblasts. Miro1 Reducer reduces Miro1 protein levels in dose-dependent manner (IC₅₀ = 7.8 mM).

For research use only. We do not sell to patients.

Miro1 Reducer Chemical Structure

CAS No. : 2624336-91-8

Size	Price	Stock	Quantity
5 mg	USD 330	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

425.85

Formula

C₂₀H₁₇ClFN₇O

CAS No.

2624336-91-8

SMILES

O=C(NC1=CC(F)=CC=C1)NC2=CC=C(NC3=NC=NC(N4C=NC=C4)=C3)C=C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 42.58 mg/mL (99.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3482 mL	11.7412 mL	23.4824 mL
5 mM	0.4696 mL	2.3482 mL	4.6965 mL
10 mM	0.2348 mL	1.1741 mL	2.3482 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hsieh CH, et al. Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models. Cell Metab. 2019 Dec 3;30(6):1131-1140.e7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3482 mL	11.7412 mL	23.4824 mL	58.7061 mL
	5 mM	0.4696 mL	2.3482 mL	4.6965 mL	11.7412 mL
	10 mM	0.2348 mL	1.1741 mL	2.3482 mL	5.8706 mL
	15 mM	0.1565 mL	0.7827 mL	1.5655 mL	3.9137 mL
	20 mM	0.1174 mL	0.5871 mL	1.1741 mL	2.9353 mL
	25 mM	0.0939 mL	0.4696 mL	0.9393 mL	2.3482 mL
	30 mM	0.0783 mL	0.3914 mL	0.7827 mL	1.9569 mL
	40 mM	0.0587 mL	0.2935 mL	0.5871 mL	1.4677 mL
	50 mM	0.0470 mL	0.2348 mL	0.4696 mL	1.1741 mL
	60 mM	0.0391 mL	0.1957 mL	0.3914 mL	0.9784 mL
	80 mM	0.0294 mL	0.1468 mL	0.2935 mL	0.7338 mL

Miro1 Reducer Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Miro1 Reducer2624336-91-8OthersParkinson's diseasefibroblastsMiro1mitophagyInhibitorinhibitorinhibit

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