Miro1 Reducer
Based on 1 Customer Validation
Miro1 Reducer is a small molecule that can repair this defect of Miro1 in Parkinson's disease (PD) fibroblasts. Miro1 Reducer reduces the delayed mitophagy phenotype in PD fibroblasts. Miro1 Reducer reduces Miro1 protein levels in dose-dependent manner (IC50 = 7.8 mM).
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 2624336-91-8
- Formula: C20H17ClFN7O
- Molecular Weight:425.85
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Autophagy Compound Library
HY-L029
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Anti-Aging Compound Library
HY-L034
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Mitochondria-Targeted Compound Library
HY-L089
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Mitophagy Compound Library
HY-L180
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MCE Bioactive Compound Library
HY-L001V
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Miro1 Reducer (10 μM; 30 h) promotes Miro1 degradation following CCCP (HY-100941) treatment in fibroblasts from a sporadic PD patient[1].
Miro1 Reducer (5 μM; 30 h) can completely rescue stress-induced neurodegeneration in dopaminergic neurons derived from PD patients[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2624336-91-8
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Appearance Solid
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Molecular Weight 425.85
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Formula C20H17ClFN7O
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Color Off-white to yellow
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SMILES
O=C(NC1=CC(F)=CC=C1)NC2=CC=C(NC3=NC=NC(N4C=NC=C4)=C3)C=C2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 62.5 mg/mL (146.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3482 mL | 11.7412 mL | 23.4824 mL | 58.7061 mL |
| 5 mM | 0.4696 mL | 2.3482 mL | 4.6965 mL | 11.7412 mL | |
| 10 mM | 0.2348 mL | 1.1741 mL | 2.3482 mL | 5.8706 mL | |
| 15 mM | 0.1565 mL | 0.7827 mL | 1.5655 mL | 3.9137 mL | |
| 20 mM | 0.1174 mL | 0.5871 mL | 1.1741 mL | 2.9353 mL | |
| 25 mM | 0.0939 mL | 0.4696 mL | 0.9393 mL | 2.3482 mL | |
| 30 mM | 0.0783 mL | 0.3914 mL | 0.7827 mL | 1.9569 mL | |
| 40 mM | 0.0587 mL | 0.2935 mL | 0.5871 mL | 1.4677 mL | |
| 50 mM | 0.0470 mL | 0.2348 mL | 0.4696 mL | 1.1741 mL | |
| 60 mM | 0.0391 mL | 0.1957 mL | 0.3914 mL | 0.9784 mL | |
| 80 mM | 0.0294 mL | 0.1468 mL | 0.2935 mL | 0.7338 mL | |
| 100 mM | 0.0235 mL | 0.1174 mL | 0.2348 mL | 0.5871 mL |
Miro1 Reducer Related Classifications
HY-163172 Related Classifications
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