1. Metabolic Enzyme/Protease
  2. Proteasome
  3. ML604440

ML604440 

Cat. No.: HY-114170
Handling Instructions

ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor. ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE.

For research use only. We do not sell to patients.

ML604440 Chemical Structure

ML604440 Chemical Structure

CAS No. : 1140517-08-3

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Description

ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1]. ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].

IC50 & Target

proteasome β1i (LMP2) subunit inhibitor[1]

Molecular Weight

388.19

Formula

C₁₇H₂₄BF₃N₂O₄

CAS No.

1140517-08-3

SMILES

CC(C)C[[email protected]@H](B(O)O)NC(C(NC(C1=CC=CC=C1C(F)(F)F)=O)(C)C)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ML604440
Cat. No.:
HY-114170
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